Publications

CEMB Faculty Publications 2020 (partial)

Basu, D., & Haswell, E. S. (2020). The mechanosensitive ion channel MSL10 potentiates responses to cell swelling in Arabidopsis seedlings. Current Biology, 30, 1-13. https://doi.org/10.1016/j.cub.2020.05.015

Basu, D., Shoots, J. M., Harkess, A., Veley, K. M., & Haswell, E. S. (2019). Interactions between the N- and C- termini of mechanosensitive ion channel AtMSL10 support a three-step mechanism for activating its signaling function. Journal of Experimental Botany. IN PRESS

Boyle, J. J., Pless, R. B., Thomopoulos, S., & Genin, G. M. (2020). Direct estimation of surface strain fields from a stereo vision system. Journal of Biomechanical Engineering, 142(7). https://doi.org/10.1115/1.4045813

Caporizzo, M. A., Chen, C. Y., Bedi, K., Margulies, K. B., & Prosser, B. L. (2020). Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium. Circulation, 141(11), 902–915. https://doi.org/10.1161/CIRCULATIONAHA.119.043930

Cardenas Turner, J., Collins, G., Blaber, E. A., Almeida, E. A. C., & Arinzeh, T. L. (2020). Evaluating the cytocompatibility and differentiation of bone progenitors on electrospun zein scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 14(1), 173–185. https://doi.org/10.1002/term.2984

Chen, C. Y., Salomon, A. K., Caporizzo, M. A., Curry, S., Kelly, N. A., Bedi, K. C., Bogush, A. I., Krämer, E., Schlossarek, S., Janiak, P., Moutin, M.-J., Carrier, L., Margulies, K. B., & Prosser, B. L. (2020). Depletion of vasohibin 1 speeds contraction and relaxation in failing human cardiomyocytes. Circulation Research, https://doi.org/10.1161/CIRCRESAHA.119.315947

Cheng, B., Wan, W., Huang, G., Li, Y., Genin, G. M., Mofrad, M. R. K., Lu, T. J., Xu, F., & Lin, M. (2020). Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation. Science Advances, 6(10), eaax1909. https://doi.org/10.1126/sciadv.aax1909

Dai, E. N., Heo, S.-J., & Mauck, R. L. (2020). “Looping In” mechanics: Mechanobiologic regulation of the nucleus and the epigenome. Advanced Healthcare Materials, 2000030. https://doi.org/10.1002/adhm.202000030

Daly, A. C., Riley, L., Segura, T., & Burdick, J. A. (2020). Hydrogel microparticles for biomedical applications. Nature Reviews Materials, 5(1), 20–43. https://doi.org/10.1038/s41578-019-0148-6

Davidson, M. D., Ban, E., Schoonen, A. C. M., Lee, M., D’Este, M., Shenoy, V. B., & Burdick, J. A. (2020). Mechanochemical adhesion and plasticity in multifiber hydrogel networks. Advanced Materials, 32(8), 1905719. https://doi.org/10.1002/adma.201905719

Davidson, M. D., Burdick, J. A., & Wells, R. G. (2020). Engineered biomaterial platforms to study fibrosis. Advanced Healthcare Materials, 1901682. https://doi.org/10.1002/adhm.201901682

Eftekhari, B. S., Eskandari, M., Janmey, P. A., Samadikuchaksaraei, A., & Gholipourmalekabadi, M. (2020). Surface topography and electrical signaling: single and synergistic effects on neural differentiation of stem cells. Advanced Functional Materials, 1907792. https://doi.org/10.1002/adfm.201907792

Hayes, B. H., Tsai, R. K., Dooling, L. J., Kadu, S., Lee, J. Y., Pantano, D., Rodriguez, P. L., Subramanian, S., Shin, J. W., & Discher, D. E. (2020). Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα. Journal of Cell Science, 133(5). https://doi.org/10.1242/jcs.237800

Heffler, J., Shah, P. P., Robison, P., Phyo, S., Veliz, K., Uchida, K., Bogush, A., Rhoades, J., Jain, R., & Prosser, B. L. (2020). A balance between intermediate filaments and microtubules maintains nuclear architecture in the cardiomyocyte. Circulation Research, 126(3), e10–e26. https://doi.org/10.1161/CIRCRESAHA.119.315582

Heo, K., Thakur, S., Miller, L. M., Cao, X., Peredo, A. P., Seiber, B. N., Qu, F., Driscoll,T. P., Shenoy, V. B., Lakadamyali, M., Burdick, J. A., Mauck, R. L. (2020)
Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues.  Science Advances, IN PRESS

Homayouni, A. L., & Strader, L. C. (2020). Sugar rush: Glucosylation of IPyA attenuates auxin levels. Proceedings of the National Academy of Sciences, 117(14), 202003305. https://doi.org/10.1073/pnas.2003305117

Huang, H., & Dean, D. (2020). 3-D printed porous cellulose acetate tissue scaffolds for additive manufacturing. Additive Manufacturing, 31, 100927. https://doi.org/10.1016/j.addma.2019.100927

Janmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020). Stiffness sensing by cells. Physiological Reviews, 100(2), 695–724. https://doi.org/10.1152/physrev.00013.2019

Ji, H. H., & Ostap, E. M. (2020). The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation. Journal of Biological Chemistry, 295(12), 3749–3756. https://doi.org/10.1074/jbc.RA119.011227

Ji, S., Abaci, A., Morrison, T., Gramlich, W. M., & Guvendiren, M. (2020). Novel bioinks from UV-responsive norbornene-functionalized carboxymethyl cellulose macromers. Bioprinting, 18, e00083. https://doi.org/10.1016/j.bprint.2020.e00083

Lakadamyali, M., & Cosma, M. P. (2020). Visualizing the genome in high resolution challenges our textbook understanding. Nature Methods, 17(4), 371–379. https://doi.org/10.1038/s41592-020-0758-3

Linari, M., Piazzesi, G., Pertici, I., Dantzig, J. A., Goldman, Y. E., & Lombardi, V. (2020). Straightening out the elasticity of myosin cross-bridges. Biophysical Journal, 118(5), 994–1002.  https://doi.org/10.1016/j.bpj.2020.01.002

Liu, J., Gao, Y., Wang, H., Poling-Skutvik, R., Osuji, C. O., & Yang, S. (2020). Shaping and locomotion of soft robots using filament actuators made from liquid crystal elastomer–carbon nanotube composites. Advanced Intelligent Systems, 1900163. https://doi.org/10.1002/aisy.201900163.  IN PRESS.

Liu, Y., Schwartz, A. G., Hong, Y., Peng, X., Xu, F., Thomopoulos, S., & Genin, G. M. (2020). Correction of bias in the estimation of cell volume fraction from histology sections. Journal of Biomechanics, 109705. https://doi.org/10.1016/j.jbiomech.2020.109705

Loebel, C., Kwon, M. Y., Wang, C., Han, L., Mauck, R. L., & Burdick, J. A. (2020). Metabolic labeling to probe the spatiotemporal accumulation of matrix at the chondrocyte-hydrogel interface. Advanced Functional Materials, 1909802. https://doi.org/10.1002/adfm.201909802

Mandal, K., Gong, Z., Rylander, A., Shenoy, V. B., & Janmey, P. A. (2020). Opposite responses of normal hepatocytes and hepatocellular carcinoma cells to substrate viscoelasticity. Biomaterials Science, 8(5), 1316–1328. https://doi.org/10.1039/c9bm01339c

Monslow, J., Todd, L., Chojnowski, J. E., Govindaraju, P. K., Assoian, R. K., & Puré, E. (2020). Fibroblast activation protein regulates lesion burden and the fibroinflammatory response in apoe-deficient mice in a sexually dimorphic manner. The American Journal of Pathology, 0(0). https://doi.org/10.1016/j.ajpath.2020.01.004

Mugnai, M. L., Caporizzo, M. A., Goldman, Y. E., & Thirumalai, D. (2020). Processivity and velocity for motors stepping on periodic tracks. Biophysical Journal, 118(7), 1537–1551. https://doi.org/10.1016/j.bpj.2020.01.047

Powers, S. K., & Strader, L. C. (2020). Regulation of auxin transcriptional responses. Developmental Dynamics, 249(4), 483–495. https://doi.org/10.1002/dvdy.139

Saini, K., Cho, S., Dooling, L. J., & Discher, D. E. (2020). Tension in fibrils suppresses their enzymatic degradation – A molecular mechanism for ‘use it or lose it.’ Matrix Biology, 85–86, 34–46. https://doi.org/10.1016/j.matbio.2019.06.001

Schlegel, A. M., & Haswell, E. S. (2020). Plant biomechanics: no pain, no gain for birch tree stems. Current Biology, 30(4), R164–R166. https://doi.org/10.1016/j.cub.2019.12.069

Schlegel, A. M., & Haswell, E. S. (2020). Analyzing plant mechanosensitive ion channels expressed in giant E. coli spheroplasts by single-channel patch-clamp electrophysiology. In Methods in Cell Biology. Academic Press Inc. https://doi.org/10.1016/bs.mcb.2020.02.007

Seo, B. R., Chen, X., Ling, L., Shimpi, A. A., Song, Y. H., Choi, S., Gonzalez, J., Sapudom, J., Wang, K., Eguiluz, R. C. A., Gourdon, D., Shenoy, V. B., Fischbach, C. (2020).
Collagen microstructure mechanically controls myofibroblast differentiation
Proceedings Of The National Academy Of Sciences, IN PRESS

Shakiba, D., Alisafaei, F., Savadipour, A., Rowe, R. A., Liu, Z., Pryse, K. M., Shenoy, V. B., Elson, E. L., & Genin, G. M. (2020). The balance between actomyosin contractility and microtubule polymerization regulates hierarchical protrusions that govern efficient fibroblast-collagen interactions. ACS Nano, https://doi.org/10.1021/acsnano.9b09941

Wang, M., Liu, S., Xu, Z., Qu, K., Li, M., Chen, X., Xue, Q., Genin, G. M., Lu, T. J., & Xu, F. (2020). Characterizing poroelasticity of biological tissues by spherical indentation: An improved theory for large relaxation. Journal of the Mechanics and Physics of Solids, 138, 103920. https://doi.org/10.1016/j.jmps.2020.103920

Zhang, J., Alisafaei, F., Nikolić, M., Nou, X. A., Kim, H., Shenoy, V. B., & Scarcelli, G. (2020). Nuclear mechanics within intact cells is regulated by cytoskeletal network and internal nanostructures. Small, 1907688. https://doi.org/10.1002/smll.201907688

CEMB Faculty Publications 2019

Alisafaei, F., Jokhun, D. S., Shivashankar, G. V., & Shenoy, V. B. (2019). Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints. Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13200–13209. https://doi.org/10.1073/pnas.1902035116

Assoian, R. K., Bade, N. D., Cameron, C. V., & Stebe, K. J. (2019). Cellular sensing of micron-scale curvature: a frontier in understanding the microenvironment. Open Biology, 9(10), 190155. https://doi.org/10.1098/rsob.190155

Avgoulas, E. I., Sutcliffe, M. P. F., Linderman, S. W., Birman, V., Thomopoulos, S., & Genin, G. M. (2019). Adhesive-based tendon-to-bone repair: failure modelling and materials selection. Journal of The Royal Society Interface, 16(153), 20180838. https://doi.org/10.1098/rsif.2018.0838

Ban, E., Wang, H., Matthew Franklin, J., Liphardt, J. T., Janmey, P. A., & Shenoy, V. B. (2019). Strong triaxial coupling and anomalous Poisson effect in collagen networks. Proceedings of the National Academy of Sciences of the United States of America, 116(14), 6790–6799. https://doi.org/10.1073/pnas.1815659116

Bonnevie, E. D., Gullbrand, S. E., Ashinsky, B. G., Tsinman, T. K., Elliott, D. M., Chao, P. Hsiu G., Smith, H. E., & Mauck, R. L. (2019). Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss. Nature Biomedical Engineering, 3(12), 998–1008. https://doi.org/10.1038/s41551-019-0458-4

Borodinov, N., Bilkey, N., Foston, M., Ievlev, A. V., Belianinov, A., Jesse, S., Vasudevan, R. K., Kalinin, S. V., & Ovchinnikova, O. S. (2019). Application of pan-sharpening algorithm for correlative multimodal imaging using AFM-IR. Npj Computational Materials, 5(1), 1–9. https://doi.org/10.1038/s41524-019-0186-z

Borodinov, N., Bilkey, N., Foston, M., Ievlev, A. V., Belianinov, A., Jesse, S., Vasudevan, R. K., Kalinin, S. V., & Ovchinnikova, O. S. (2019). Spectral map reconstruction using pan-sharpening algorithm: enhancing chemical imaging with AFM-IR. Microscopy and Microanalysis, 25(S2), 1024–1025. https://doi.org/10.1017/s1431927619005853

Boyle, J. J., Soepriatna, A., Damen, F., Rowe, R. A., Pless, R. B., Kovacs, A., Goergen, C. J., Thomopoulos, S., & Genin, G. M. (2019). Regularization-free strain mapping in three dimensions, with application to cardiac ultrasound. Journal of Biomechanical Engineering, 141(1). https://doi.org/10.1115/1.4041576

Brankovic, S. A., Hawthorne, E. A., Yu, X., Zhang, Y., & Assoian, R. K. (2019). MMP12 deletion preferentially attenuates axial stiffening of aging arteries. Journal of Biomechanical Engineering, 141(8) 081004. https://doi.org/10.1115/1.4043322

Burkart, G. M., & Dixit, R. (2019). Microtubule bundling by MAP65-1 protects against severing by inhibiting the binding of katanin. Molecular Biology of the Cell, 30(13), 1587–1597. https://doi.org/10.1091/mbc.E18-12-0776

Chen, X., He, W., Liu, S., Li, M., Genin, G. M., Xu, F., & Lu, T. J. (2019). Volumetric response of an ellipsoidal liquid inclusion: implications for cell mechanobiology. Acta Mechanica Sinica/Lixue Xuebao, 35(2), 338–342. https://doi.org/10.1007/s10409-019-00850-5

Chen, X., Li, M., Liu, S., Liu, F., Genin, G. M., Xu, F., & Lu, T. J. (2019). Translation of a coated rigid spherical inclusion in an elastic matrix: Exact solution, and implications for mechanobiology. Journal of Applied Mechanics, Transactions ASME, 86(5). https://doi.org/10.1115/1.4042575

Cho, S., Vashisth, M., Abbas, A., Majkut, S., Vogel, K., Xia, Y., Ivanovska, I. L., Irianto, J., Tewari, M., Zhu, K., Tichy, E. D., Mourkioti, F., Tang, H. Y., Greenberg, R. A., Prosser, B. L., & Discher, D. E. (2019). Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell, 49(6), 920-935.e5. https://doi.org/10.1016/j.devcel.2019.04.020

Corbin, E. A., Vite, A., Peyster, E. G., Bhoopalam, M., Brandimarto, J., Wang, X., Bennett, A. I., Clark, A. T., Cheng, X., Turner, K. T., Musunuru, K., & Margulies, K. B. (2019). Tunable and reversible substrate stiffness reveals a dynamic mechanosensitivity of cardiomyocytes. ACS Applied Materials and Interfaces, 11(23), 20603–20614. https://doi.org/10.1021/acsami.9b02446

Damodaran, S., & Strader, L. C. (2019). Indole 3-butyric acid metabolism and transport in Arabidopsis thaliana. Frontiers in Plant Science, 10, 851. https://doi.org/10.3389/fpls.2019.00851

Davidson, M. D., Song, K. H., Lee, M. H., Llewellyn, J., Du, Y., Baker, B. M., Wells, R. G., & Burdick, J. A. (2019). Engineered fibrous networks to investigate the influence of fiber mechanics on myofibroblast differentiation. ACS Biomaterials Science and Engineering, 5(8), 3899–3908. https://doi.org/10.1021/acsbiomaterials.8b01276

del Campo, L., Sánchez‐López, A., Salaices, M., von Kleeck, R. A., Expósito, E., González‐Gómez, C., Cussó, L., Guzmán‐Martínez, G., Ruiz‐Cabello, J., Desco, M., Assoian, R. K., Briones, A. M., & Andrés, V. (2019). Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite. Aging Cell, 18(3), e12936. https://doi.org/10.1111/acel.12936

Discher, D. E. (2019). From DNA damage to epithelial integrity: New roles for cell forces. Molecular Biology of the Cell, 30 (16), 1879–1881. https://doi.org/10.1091/mbc.E19-06-0338

Du, Y., Khandekar, G., Llewellyn, J., Polacheck, W., Chen, C. S., & Wells, R. G. (2019). A bile duct‐on‐a‐chip with organ‐level functions. Hepatology, 71(4), 1350–1363. https://doi.org/10.1002/hep.30918

Frank, D. B., Penkala, I. J., Zepp, J. A., Sivakumar, A., Linares-Saldana, R., Zacharias, W. J., Stolz, K. G., Pankin, J., Lu, M. Q., Wang, Q., Babu, A., Li, L., Zhou, S., Morley, M. P., Jain, R., & Morrisey, E. E. (2019). Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4362–4371. https://doi.org/10.1073/pnas.1813952116

Highley, C. B., Song, K. H., Daly, A. C., & Burdick, J. A. (2019). Jammed microgel inks for 3D printing applications. Advanced Science, 6(1), 1801076. https://doi.org/10.1002/advs.201801076

Huang, G., Xu, F., Genin, G. M., & Lu, T. J. (2019). Mechanical microenvironments of living cells: a critical frontier in mechanobiology. Acta Mechanica Sinica/Lixue Xuebao, 35(2), 265–269. https://doi.org/10.1007/s10409-019-00854-1

Jamiolkowski, R. M., Chen, K. Y., Fiorenza, S. A., Tate, A. M., Pfeil, S. H., & Goldman, Y. E. (2019). Nanoaperture fabrication via colloidal lithography for single molecule fluorescence analysis. PLOS ONE, 14(10), e0222964. https://doi.org/10.1371/journal.pone.0222964

Ji, S., Almeida, E., & Guvendiren, M. (2019). 3D bioprinting of complex channels within cell-laden hydrogels. Acta Biomaterialia, 95, 214–224. https://doi.org/10.1016/j.actbio.2019.02.038

Ji, S., & Guvendiren, M. (2019). 3D printed wavy scaffolds enhance mesenchymal stem cell osteogenesis. Micromachines, 11(1), 31. https://doi.org/10.3390/mi11010031

Jiang, S., Lyu, C., Zhao, P., Li, W., Kong, W., Huang, C., Genin, G. M., & Du, Y. (2019). Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D. Nature Communications, 10(1), 1–14. https://doi.org/10.1038/s41467-019-11397-1

Jiang, Y., Xu, B., Melnykov, A., Genin, G. M., & Elson, E. L. (2019). Fluorescence correlation spectroscopy and photon counting histograms in small domains. Part I: General theory. BioRxiv, 847129. https://doi.org/10.1101/847129

Jiang, Y., Pryse, K. M., Singamaneni, S., Genin, G. M., & Elson, E. L. (2019). Atomic force microscopy of phase separation on ruptured, giant unilamellar vesicles, and a mechanical pathway for the co-existence of lipid gel phases. Journal of Biomechanical Engineering, 141(7). https://doi.org/10.1115/1.4043871

Jing, H., & Strader, L. (2019). Interplay of auxin and cytokinin in lateral root development. International Journal of Molecular Sciences, 20(3), 486. https://doi.org/10.3390/ijms20030486

Joshi, H., & Morley, S. C. (2019). Cells under stress: The mechanical environment shapes inflammasome responses to danger signals. Journal of Leukocyte Biology, 106(1), 119–125. https://doi.org/10.1002/JLB.3MIR1118-417R

Kaur, A., Ecker, B. L., Douglass, S. M., Kugel, C. H., Webster, M. R., Almeida, F. V., Somasundaram, R., Hayden, J., Ban, E., Ahmadzadeh, H., Franco-Barraza, J., Shah, N., Mellis, I. A., Keeney, F., Kossenkov, A., Tang, H. Y., Yin, X., Liu, Q., Xu, X.,  Fane M., Brafford P., Herlyn M., Speicher D.W, Wargo J., Tetzlaff M., Haydu L., Raj A., Shenoy V.B., Cukierman E., and Weeraratna A.T. (2019). Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility. Cancer Discovery, 9(1), 64–81. https://doi.org/10.1158/2159-8290.CD-18-0193

Kieckhaefer, J. E., Maina, F., Wells, R. G., & Wangensteen, K. J. (2019). Liver cancer gene discovery using gene targeting, sleeping beauty, and CRISPR/Cas9. Seminars in Liver Disease, 39(2), 261–274. https://doi.org/10.1055/s-0039-1678725

Kleeck, R. von, Brankovic, S. A., Roberts, I., Hawthorne, E. A., Bruun, K., Castagnino, P., & Assoian, R. K. (2019). Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition. BioRxiv, 773184. https://doi.org/10.1101/773184

Lee, J. S., Wilson, M. E., Richardson, R. A., & Haswell, E. S. (2019). Genetic and physical interactions between the organellar mechanosensitive ion channel homologs MSL1, MSL2, and MSL3 reveal a role for inter-organellar communication in plant development. Plant Direct, 3(3), e00124. https://doi.org/10.1002/pld3.124

Leiphart, R. J., Chen, D., Peredo, A. P., Loneker, A. E., & Janmey, P. A. (2019). Mechanosensing at cellular interfaces. Langmuir, 35(23), 7509–7519. https://doi.org/10.1021/acs.langmuir.8b02841

Liu, S., Tao, R., Wang, M., Tian, J., Genin, G. M., Lu, T. J., & Xu, F. (2019). Regulation of cell behavior by hydrostatic pressure. Applied Mechanics Reviews, 71(4). https://doi.org/10.1115/1.4043947

Liu, S., Yang, H., Lu, T. J., Genin, G. M., & Xu, F. (2019). Electrostatic switching of nuclear basket conformations provides a potential mechanism for nuclear mechanotransduction. Journal of the Mechanics and Physics of Solids, 133, 103705. https://doi.org/10.1016/j.jmps.2019.103705

Liu, S. lin, Bajpai, A., Hawthorne, E. A., Bae, Y., Castagnino, P., Monslow, J., Puré, E., Spiller, K. L., & Assoian, R. K. (2019). Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI Insight, 4(1). https://doi.org/10.1172/jci.insight.122742

Loebel, C., Mauck, R. L., & Burdick, J. A. (2019). Local nascent protein deposition and remodeling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels. Nature Materials, 18(8), 883–891. https://doi.org/10.1038/s41563-019-0307-6

Ma, S., Zhu, M., Xia, X., Guo, L., Genin, G. M., Sacks, M. S., Gao, M., Mutic, S., Hu, Y., Hu, C., & Feng, Y. (2019). A preliminary study of the local biomechanical environment of liver tumors in vivo. Medical Physics, 46(4), 1728–1739. https://doi.org/10.1002/mp.13434

Malik, R., Luong, T., Cao, X., Han, B., Shah, N., Franco-Barraza, J., Han, L., Shenoy, V. B., Lelkes, P. I., & Cukierman, E. (2019). Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2. Matrix Biology, 81, 50–69. https://doi.org/10.1016/j.matbio.2018.11.001

Mandal, K., Pogoda, K., Nandi, S., Mathieu, S., Kasri, A., Klein, E., Radvanyi, F., Goud, B., Janmey, P. A., & Manneville, J. B. (2019). Role of a kinesin motor in cancer cell mechanics. Nano Letters, 19(11), 7691–7702. https://doi.org/10.1021/acs.nanolett.9b02592

Mandal, K., Raz-Ben Aroush, D., Graber, Z. T., Wu, B., Park, C. Y., Fredberg, J. J., Guo, W., Baumgart, T., & Janmey, P. A. (2019). Soft hyaluronic gels promote cell spreading, stress fibers, focal adhesion, and membrane tension by phosphoinositide signaling, not traction force. ACS Nano, 13(1), 203–214. https://doi.org/10.1021/acsnano.8b05286

Mason, D. E., Collins, J. M., Dawahare, J. H., Nguyen, T. D., Lin, Y., Voytik-Harbin, S. L., Zorlutuna, P., Yoder, M. C., & Boerckel, J. D. (2019). YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility. Journal of Cell Biology, 218(4), 1369–1389. https://doi.org/10.1083/jcb.201806065

McDermott, A. M., Herberg, S., Mason, D. E., Collins, J. M., Pearson, H. B., Dawahare, J. H., Tang, R., Patwa, A. N., Grinstaff, M. W., Kelly, D. J., Alsberg, E., & Boerckel, J. D. (2019). Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science Translational Medicine, 11(495). https://doi.org/10.1126/scitranslmed.aav7756

Menezes, R., Hashemi, S., Vincent, R., Collins, G., Meyer, J., Foston, M., & Arinzeh, T. L. (2019). Investigation of glycosaminoglycan mimetic scaffolds for neurite growth. Acta Biomaterialia, 90, 169–178. https://doi.org/10.1016/j.actbio.2019.03.024

Michniewicz, M., Ho, C.-H., Enders, T. A., Floro, E., Gunther, L. K., Damodoran, S., Powers, S. K., Frick, E. M., Topp, C. N., Frommer, W. B., & Strader, L. (2019). Transporter of IBA1 links auxin and cytokinin to influence root architecture. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3339905

Motahari, F., & Carlsson, A. E. (2019). Pulling-force generation by ensembles of polymerizing actin filaments. Physical Biology, 17(1), 016005. https://doi.org/10.1088/1478-3975/ab59bd

Motahari, F., & Carlsson, A. E. (2019). Thermodynamically consistent treatment of the growth of a biopolymer in the presence of a smooth obstacle interaction potential. Physical Review E, 100(4), 042409. https://doi.org/10.1103/PhysRevE.100.042409

Paek, J., Park, S. E., Lu, Q., Park, K. T., Cho, M., Oh, J. M., Kwon, K. W., Yi, Y. S., Song, J. W., Edelstein, H. I., Ishibashi, J., Yang, W., Myerson, J. W., Kiseleva, R. Y., Aprelev, P., Hood, E. D., Stambolian, D., Seale, P., Muzykantov, V. R., & Huh, D. (2019). Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues. ACS Nano, 13(7), 7627–7643. https://doi.org/10.1021/acsnano.9b00686

Pakshir, P., Alizadehgiashi, M., Wong, B., Coelho, N. M., Chen, X., Gong, Z., Shenoy, V. B., McCulloch, C., & Hinz, B. (2019). Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix. Nature Communications, 10(1), 1–17. https://doi.org/10.1038/s41467-019-09709-6

Park, S. E., Georgescu, A., & Huh, D. (2019). Organoids-on-a-chip. Science, 364(6444), 960–965. https://doi.org/10.1126/science.aaw7894

Patteson, A. E., Pogoda, K., Byfield, F. J., Mandal, K., Ostrowska‐Podhorodecka, Z., Charrier, E. E., Galie, P. A., Deptuła, P., Bucki, R., McCulloch, C. A., & Janmey, P. A. (2019). Loss of vimentin enhances cell motility through small confining spaces. Small, 15(50), 1903180. https://doi.org/10.1002/smll.201903180

Pfeifer, C. R., Vashisth, M., Xia, Y., & Discher, D. E. (2019). Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: A brief review. Essays in Biochemistry 63(5), 569–577. https://doi.org/10.1042/EBC20190007

Polacheck, W. J., Kutys, M. L., Tefft, J. B., & Chen, C. S. (2019). Microfabricated blood vessels for modeling the vascular transport barrier. Nature Protocols, 14(5), 1425–1454. https://doi.org/10.1038/s41596-019-0144-8

Poleshko, A., Smith, C. L., Nguyen, S. C., Sivaramakrishnan, P., Wong, K. G., Murray, J. I., Lakadamyali, M., Joyce, E. F., Jain, R., & Epstein, J. A. (2019). H3k9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. ELife, 8. https://doi.org/10.7554/eLife.49278

Powers, S. K., Holehouse, A. S., Korasick, D. A., Schreiber, K. H., Clark, N. M., Jing, H., Emenecker, R., Han, S., Tycksen, E., Hwang, I., Sozzani, R., Jez, J. M., Pappu, R. V., & Strader, L. C. (2019). Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana. Molecular Cell, 76(1), 177-190.e5. https://doi.org/10.1016/j.molcel.2019.06.044

Pyrpassopoulos, S., Shuman, H., & Ostap, E. M. (2019). Modulation of kinesin’s load-bearing capacity by force geometry and the microtubule track. Biophysical Journal, 118(1), 243–253. https://doi.org/10.1016/j.bpj.2019.10.045

Roell, G. W., Carr, R. R., Campbell, T., Shang, Z., Henson, W. R., Czajka, J. J., Martín, H. G., Zhang, F., Foston, M., Dantas, G., Moon, T. S., & Tang, Y. J. (2019). A concerted systems biology analysis of phenol metabolism in Rhodococcus opacus PD630. Metabolic Engineering, 55, 120–130. https://doi.org/10.1016/j.ymben.2019.06.013

Rowe, R. A., Pryse, K. M., Elson, E. L., & Genin, G. M. (2019). Stable fitting of noisy stress relaxation data. Mechanics of Soft Materials, 1(1), 1–14. https://doi.org/10.1007/s42558-019-0010-4

Saini, K., & Discher, D. E. (2019). Forced unfolding of proteins directs biochemical cascades. Biochemistry, 58(49), 4893–4902. https://doi.org/10.1021/acs.biochem.9b00839

See, K., Lan, Y., Rhoades, J., Jain, R., Smith, C. L., & Epstein, J. A. (2019). Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9Me2 domains. Development, 146(3). https://doi.org/10.1242/dev.174078

Seo, J., Byun, W. Y., Alisafaei, F., Georgescu, A., Yi, Y. S., Massaro-Giordano, M., Shenoy, V. B., Lee, V., Bunya, V. Y., & Huh, D. (2019). Multiscale reverse engineering of the human ocular surface. Nature Medicine, 25(8), 1310–1318. https://doi.org/10.1038/s41591-019-0531-2

Smith, L. R., Irianto, J., Xia, Y., Pfeifer, C. R., & Discher, D. E. (2019). Constricted migration modulates stem cell differentiation. Molecular Biology of the Cell, 30(16), 1985–1999. https://doi.org/10.1091/mbc.E19-02-0090

Song, K. H., Heo, S., Peredo, A. P., Davidson, M. D., Mauck, R. L., & Burdick, J. A. (2019). Influence of fiber stiffness on meniscal cell migration into dense fibrous networks. Advanced Healthcare Materials, 1901228. https://doi.org/10.1002/adhm.201901228

Stanley, A., Heo, S., Mauck, R. L., Mourkioti, F., & Shore, E. M. (2019). Elevated BMP and Mechanical signaling through YAP1/RhoA poises FOP mesenchymal progenitors for osteogenesis. Journal of Bone and Mineral Research, 34(10), 1894–1909. https://doi.org/10.1002/jbmr.3760

van Oosten, A. S. G., Chen, X., Chin, L. K., Cruz, K., Patteson, A. E., Pogoda, K., Shenoy, V. B., & Janmey, P. A. (2019). Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells. Nature, 573 (7772), 96–101. https://doi.org/10.1038/s41586-019-1516-5

Woody, M. S., Winkelmann, D. A., Capitanio, M., Ostap, E. M., & Goldman, Y. E. (2019). Single molecule mechanics resolves the earliest events in force generation by cardiac myosin. ELife, 8. https://doi.org/10.7554/eLife.49266

Xia, Y., Cho, S., Vashisth, M., Ivanovska, I. L., Dingal, P. C. D. P., & Discher, D. E. (2019). Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods, 157, 3–14. https://doi.org/10.1016/j.ymeth.2018.12.009

Xia, Y., Pfeifer, C. R., & Discher, D. E. (2019). Nuclear mechanics during and after constricted migration. Acta Mechanica Sinica/Lixue Xuebao, 35(2), 299–308. https://doi.org/10.1007/s10409-018-00836-9

Xia, Y., Pfeifer, C. R., Zhu, K., Irianto, J., Liu, D., Pannell, K., Chen, E. J., Dooling, L. J., Tobin, M. P., Wang, M., Ivanovska, I. L., Smith, L. R., Greenberg, R. A., & Discher, D. E. (2019). Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of Cell Biology, 218(8), 2545–2563. https://doi.org/10.1083/jcb.201811100

Yoon, C., Choi, C., Stapleton, S., Mirabella, T., Howes, C., Dong, L., King, J., Yang, J., Oberai, A., Eyckmans, J., & Chen, C. S. (2019). Myosin IIA–mediated forces regulate multicellular integrity during vascular sprouting. Molecular Biology of the Cell, 30(16), 1974–1984. https://doi.org/10.1091/mbc.E19-02-0076

Zhou, D., Hao, J., Clark, A., Kim, K., Zhu, L., Liu, J., Cheng, X., & Li, B. (2019). Sono-assisted surface energy driven assembly of 2D materials on flexible polymer substrates: A green assembly method using water. ACS Applied Materials and Interfaces, 11(36), 33458–33464. https://doi.org/10.1021/acsami.9b10469

CEMB Faculty Publications 2018

Babaei, B., Velasquez-Mao, A. J., Pryse, K. M., McConnaughey, W. B., Elson, E. L., & Genin, G. M. (2018). Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix. Journal of the Mechanical Behavior of Biomedical Materials, 84, 198–207. https://doi.org/10.1016/j.jmbbm.2018.05.011

Bade, N. D., Kamien, R. D., Assoian, R. K., & Stebe, K. J. (2018). Edges impose planar alignment in nematic monolayers by directing cell elongation and enhancing migration. Soft Matter, 14(33), 6867–6874. https://doi.org/10.1039/c8sm00612a

Bade, N. D., Xu, T., Kamien, R. D., Assoian, R. K., & Stebe, K. J. (2018). Gaussian Curvature Directs stress fiber orientation and cell migration. Biophysical Journal, 114(6), 1467–1476. https://doi.org/10.1016/j.bpj.2018.01.039

Ban, E., Franklin, J. M., Nam, S., Smith, L. R., Wang, H., Wells, R. G., Chaudhuri, O., Liphardt, J. T., & Shenoy, V. B. (2018). Mechanisms of plastic deformation in collagen networks induced by cellular forces. Biophysical Journal, 114(2), 450–461. https://doi.org/10.1016/j.bpj.2017.11.3739

Benias, P. C., Wells, R. G., Sackey-Aboagye, B., Klavan, H., Reidy, J., Buonocore, D., Miranda, M., Kornacki, S., Wayne, M., Carr-Locke, D. L., & Theise, N. D. (2018). Structure and distribution of an unrecognized interstitium in human tissues. Scientific Reports, 8(1), 1–8. https://doi.org/10.1038/s41598-018-23062-6

Caporizzo, M. A., Fishman, C. E., Sato, O., Jamiolkowski, R. M., Ikebe, M., & Goldman, Y. E. (2018). The antiparallel dimerization of myosin x imparts bundle selectivity for processive motility. Biophysical Journal, 114(6), 1400–1410. https://doi.org/10.1016/j.bpj.2018.01.038

Caporizzo, M. A., Chen, C. Y., Salomon, A. K., Margulies, K. B., & Prosser, B. L. (2018). Microtubules provide a viscoelastic resistance to myocyte motion. Biophysical Journal, 115(9), 1796–1807. https://doi.org/10.1016/j.bpj.2018.09.019

Carlsson, A. E. (2018). Membrane bending by actin polymerization. Current Opinion in Cell Biology, 50, 1–7. https://doi.org/10.1016/j.ceb.2017.11.007

Charrier, E. E., Pogoda, K., Wells, R. G., & Janmey, P. A. (2018). Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nature Communications, 9(1), 1–13. https://doi.org/10.1038/s41467-018-02906-9

Chen, C. Y., Caporizzo, M. A., Bedi, K., Vite, A., Bogush, A. I., Robison, P., Heffler, J. G., Salomon, A. K., Kelly, N. A., Babu, A., Morley, M. P., Margulies, K. B., & Prosser, B. L. (2018). Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature Medicine, 24(8), 1225–1233. https://doi.org/10.1038/s41591-018-0046-2

Chen, X., Li, M., Yang, M., Liu, S., Genin, G. M., Xu, F., & Lu, T. J. (2018). The elastic fields of a compressible liquid inclusion. Extreme Mechanics Letters, 22, 122–130. https://doi.org/10.1016/j.eml.2018.06.002

Damodaran, K., Venkatachalapathy, S., Alisafaei, F., Radhakrishnan, A. V., Sharma Jokhun, D., Shenoy, V. B., & Shivashankar, G. V. (2018). Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response. Molecular Biology of the Cell, 29(25), 3039–3051. https://doi.org/10.1091/mbc.E18-04-0256

Discher, D. E. (2018). Biomembrane mechanical properties direct diverse cell functions. In Physics of Biological Membranes (pp. 263–285). Springer International Publishing. https://doi.org/10.1007/978-3-030-00630-3_11

Fan, Y., Burkart, G. M., & Dixit, R. (2018). The Arabidopsis SPIRAL2 protein targets and stabilizes microtubule minus ends. Current Biology, 28(6), 987-994.e3. https://doi.org/10.1016/j.cub.2018.02.014

Freedman, B. R., Rodriguez, A. B., Leiphart, R. J., Newton, J. B., Ban, E., Sarver, J. J., Mauck, R. L., Shenoy, V. B., & Soslowsky, L. J. (2018). Dynamic loading and tendon healing affect multiscale tendon properties and ECM stress transmission. Scientific Reports, 8(1), 1–13. https://doi.org/10.1038/s41598-018-29060-y

Ganguly, A., DeMott, L., Zhu, C., McClosky, D. D., Anderson, C. T., & Dixit, R. (2018). Importin-β directly regulates the motor activity and turnover of a kinesin-4. Developmental Cell, 44(5), 642-651.e5. https://doi.org/10.1016/j.devcel.2018.01.027

Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A., & Shenoy, V. B. (2018). Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates. Proceedings of the National Academy of Sciences of the United States of America, 115(12), E2686–E2695. https://doi.org/10.1073/pnas.1716620115

Haswell, E. S., & Dixit, R. (2018). Counting what counts: the importance of quantitative approaches to studying plant cell biology. Current Opinion in Plant Biology, 46, A1–A3. https://doi.org/10.1016/j.pbi.2018.10.003

Heo, S.-J., Cosgrove, B. D., Dai, E. N., & Mauck, R. L. (2018). Mechano-adaptation of the stem cell nucleus. Nucleus, 9(1), 9–19. https://doi.org/10.1080/19491034.2017.1371398

Holle, A. W., Young, J. L., Van Vliet, K. J., Kamm, R. D., Discher, D., Janmey, P., Spatz, J. P., & Saif, T. (2018). Cell-extracellular matrix mechanobiology: forceful tools and emerging needs for basic and translational research. Nano Letters,18 (1), 1–8 https://doi.org/10.1021/acs.nanolett.7b04982

Laidmäe, I., Ērglis, K., Cēbers, A., Janmey, P. A., & Uibo, R. (2018). Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation. Journal of Materials Science: Materials in Medicine, 29(12), 1–12. https://doi.org/10.1007/s10856-018-6192-8

Lebreton, G., Géminard, C., Lapraz, F., Pyrpassopoulos, S., Cerezo, D., Spéder, P., Ostap, E. M., & Noselli, S. (2018). Molecular to organismal chirality is induced by the conserved myosin 1D. Science, 362(6417), 949–952. https://doi.org/10.1126/science.aat8642

Linderman, S. W., Golman, M., Gardner, T. R., Birman, V., Levine, W. N., Genin, G. M., & Thomopoulos, S. (2018). Enhanced tendon-to-bone repair through adhesive films. Acta Biomaterialia, 70, 165–176. https://doi.org/10.1016/j.actbio.2018.01.032

Liu, J., Das, D., Yang, F., Schwartz, A. G., Genin, G. M., Thomopoulos, S., & Chasiotis, I. (2018). Energy dissipation in mammalian collagen fibrils: Cyclic strain-induced damping, toughening, and strengthening. Acta Biomaterialia, 80, 217–227. https://doi.org/10.1016/j.actbio.2018.09.027

Maksaev, G., Shoots, J. M., Ohri, S., & Haswell, E. S. (2018). Nonpolar residues in the presumptive pore-lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function. Plant Direct, 2(6), e00059. https://doi.org/10.1002/pld3.59

McIntosh, B. B., Pyrpassopoulos, S., Holzbaur, E. L. F., & Ostap, E. M. (2018). Opposing kinesin and myosin-I motors drive membrane deformation and tubulation along engineered cytoskeletal networks. Current Biology, 28(2), 236-248.e5. https://doi.org/10.1016/j.cub.2017.12.007

Mentes, A., Huehn, A., Liu, X., Zwolak, A., Dominguez, R., Shuman, H., Ostap, E. M., & Sindelar, C. V. (2018). High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. Proceedings of the National Academy of Sciences of the United States of America, 115(6), 1292–1297. https://doi.org/10.1073/pnas.1718316115

Meyer, J. R., Waghmode, S. B., He, J., Gao, Y., Hoole, D., da Costa Sousa, L., Balan, V., & Foston, M. B. (2018). Isolation of lignin from Ammonia Fiber Expansion (AFEX) pretreated biorefinery waste. Biomass and Bioenergy, 119, 446–455. https://doi.org/10.1016/j.biombioe.2018.09.017

Nebenführ, A., & Dixit, R. (2018). Kinesins and Myosins: Molecular motors that coordinate cellular functions in plants. Annual Review of Plant Biology, 69(1). 329-361. https://doi.org/10.1146/annurev-arplant-042817-040024

Pogoda, K., & Janmey, P. A. (2018). Glial tissue mechanics and mechanosensing by glial cells. Frontiers in Cellular Neuroscience, 12, 25. https://doi.org/10.3389/fncel.2018.00025

Qu, F., Li, Q., Wang, X., Cao, X., Zgonis, M. H., Esterhai, J. L., Shenoy, V. B., Han, L., & Mauck, R. L. (2018). Maturation state and matrix microstructure regulate interstitial cell migration in dense connective tissues. Scientific Reports, 8(1), 1–13. https://doi.org/10.1038/s41598-018-21212-4

Rosales, A. M., Rodell, C. B., Chen, M. H., Morrow, M. G., Anseth, K. S., & Burdick, J. A. (2018). Reversible control of network properties in azobenzene-containing hyaluronic acid-based hydrogels. Bioconjugate Chemistry, 29(4), 905–913. https://doi.org/10.1021/acs.bioconjchem.7b00802

Saadat, F., Lagieski, M. J., Birman, V., Thomopoulos, S., & Genin, G. M. (2018). Functional grading of pericellular matrix surrounding chondrocytes: potential roles in signaling and fluid transport. BioRxiv, 365569. https://doi.org/10.1101/365569

Song, J. W., Paek, J., Park, K. T., Seo, J., & Huh, D. (2018). A bioinspired microfluidic model of liquid plug-induced mechanical airway injury. Biomicrofluidics, 12(4), 042211. https://doi.org/10.1063/1.5027385

Song, K. H., Highley, C. B., Rouff, A., & Burdick, J. A. (2018). Complex 3D-printed microchannels within cell-degradable hydrogels. Advanced Functional Materials, 28(31), 1801331. https://doi.org/10.1002/adfm.201801331

Vega, S. L., Kwon, M. Y., Song, K. H., Wang, C., Mauck, R. L., Han, L., & Burdick, J. A. (2018). Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments. Nature Communications, 9(1), 1–10. https://doi.org/10.1038/s41467-018-03021-5

Wang, C., Clark, A., Yan, Z., Kong, B., & Cheng, X. (2018). Fabrication and characterization of magnetic-vortex microdiscs for applying force in mechanobiological systems. APS, 2018, A06.002. https://ui.adsabs.harvard.edu/abs/2018APS..MARA06002W/abstract

Woody, M. S., Capitanio, M., Ostap, E. M., & Goldman, Y. E. (2018). Electro-optic deflectors deliver advantages over acousto-optical deflectors in a high resolution, ultra-fast force-clamp optical trap. Optics Express, 26(9), 11181. https://doi.org/10.1364/oe.26.011181

Woody, M. S., Greenberg, M. J., Barua, B., Winkelmann, D. A., Goldman, Y. E., & Ostap, E. M. (2018). Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke. Nature Communications, 9(1), 1–11. https://doi.org/10.1038/s41467-018-06193-2

Wu, S., Chen, M.-S., Maurel, P., Lee, Y., Bunge, M. B., & Arinzeh, T. L. (2018). Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro. Journal of Neural Engineering, 15(5), 056010. https://doi.org/10.1088/1741-2552/aac77f

Xia, Y., Ivanovska, I. L., Zhu, K., Smith, L., Irianto, J., Pfeifer, C. R., Alvey, C. M., Ji, J., Liu, D., Cho, S., Bennett, R. R., Liu, A. J., Greenberg, R. A., & Discher, D. E. (2018). Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, 217(11), 3796–3808. https://doi.org/10.1083/jcb.201711161

Yu, C. K., Xu, T., Assoian, R. K., & Rader, D. J. (2018). Mining the stiffness-sensitive transcriptome in human vascular smooth muscle cells identifies long noncoding rna stiffness regulators. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(1), 164–173. https://doi.org/10.1161/ATVBAHA.117.310237

Zhao, G., Qing, H., Huang, G., Genin, G. M., Lu, T. J., Luo, Z., Xu, F., & Zhang, X. (2018). Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues. NPG Asia Materials, 10(10), 982–994. https://doi.org/10.1038/s41427-018-0092-8

Zhu, H., Yang, X., Genin, G. M., Lu, T. J., Xu, F., & Lin, M. (2018). The relationship between thiol-acrylate photopolymerization kinetics and hydrogel mechanics: An improved model incorporating photobleaching and thiol-Michael addition. Journal of the Mechanical Behavior of Biomedical Materials, 88, 160–169. https://doi.org/10.1016/j.jmbbm.2018.08.013

CEMB Faculty Publications 2017

Ahmadzadeh, H., Webster, M. R., Behera, R., Valencia, A. M. J., Wirtz, D., Weeraratna, A. T., & Shenoy, V. B. (2017). Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion. Proceedings of the National Academy of Sciences of the United States of America, 114(9), E1617–E1626. https://doi.org/10.1073/pnas.1617037114

Babaei, B., Velasquez-Mao, A. J., Thomopoulos, S., Elson, E. L., Abramowitch, S. D., & Genin, G. M. (2017). Discrete quasi-linear viscoelastic damping analysis of connective tissues, and the biomechanics of stretching. Journal of the Mechanical Behavior of Biomedical Materials, 69, 193–202. https://doi.org/10.1016/j.jmbbm.2016.12.013

Basu, D., & Haswell, E. S. (2017). Plant mechanosensitive ion channels: an ocean of possibilities. Current Opinion in Plant Biology , 40, 43–48. https://doi.org/10.1016/j.pbi.2017.07.002

Cao, X., Ban, E., Baker, B. M., Lin, Y., Burdick, J. A., Chen, C. S., & Shenoy, V. B. (2017). Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices. Proceedings of the National Academy of Sciences of the United States of America, 114(23), E4549–E4555. https://doi.org/10.1073/pnas.1620486114

Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G. M., Deshpande, V. S., Lu, T. J., & Xu, F. (2017). Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews, 22–23, 88–119. https://doi.org/10.1016/j.plrev.2017.06.016

Damaraju, S. M., Shen, Y., Elele, E., Khusid, B., Eshghinejad, A., Li, J., Jaffe, M., & Arinzeh, T. L. (2017). Three-dimensional piezoelectric fibrous scaffolds selectively promote mesenchymal stem cell differentiation. Biomaterials, 149, 51–62. https://doi.org/10.1016/j.biomaterials.2017.09.024

Frick, E. M., & Strader, L. C. (2018). Roles for IBA-derived auxin in plant development. Journal of Experimental Botany, 69(2), 169–177. https://doi.org/10.1093/jxb/erx298

Ganguly, A., DeMott, L., & Dixit, R. (2017). The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly. Journal of Cell Science, 130(7), 1232–1238. https://doi.org/10.1242/jcs.196857

Genin, G. M., Shenoy, V. B., Peng, G. C. Y., & Buehler, M. J. (2017). Integrated multiscale biomaterials experiment and modeling. ACS Biomaterials Science & Engineering, 3(11), 2628–2632. https://doi.org/10.1021/acsbiomaterials.7b00821

Hamant, O., & Haswell, E. S. (2017). Life behind the wall: Sensing mechanical cues in plants. BMC Biology, 15 (1),1–9. https://doi.org/10.1186/s12915-017-0403-5

Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017). Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment. Chemical Reviews, 117 (20), 12764–12850. https://doi.org/10.1021/acs.chemrev.7b00094

Jiang, Y., Pryse, K. M., Melnykov, A., Genin, G. M., & Elson, E. L. (2017). Investigation of Nanoscopic phase separations in lipid membranes using inverse fcs. Biophysical Journal, 112(11), 2367–2376. https://doi.org/10.1016/j.bpj.2017.04.013

Lin, M., Liu, S. B., Genin, G. M., Zhu, Y., Shi, M., Ji, C., Li, A., Lu, T. J., & Xu, F. (2017). Melting away pain: decay of thermal nociceptor transduction during heat-induced irreversible desensitization of ion channels. ACS Biomaterials Science and Engineering, 3(11), 3029–3035. https://doi.org/10.1021/acsbiomaterials.6b00789

Lipner, J., Boyle, J. J., Xia, Y., Birman, V., Genin, G. M., & Thomopoulos, S. (2017). Toughening of fibrous scaffolds by mobile mineral deposits. Acta Biomaterialia, 58, 492–501. https://doi.org/10.1016/j.actbio.2017.05.033

Lippert, L. G., Dadosh, T., Hadden, J. A., Karnawat, V., Diroll, B. T., Murray, C. B., Holzbaur, E. L. F., Schulten, K., Reck-Peterson, S. L., & Goldman, Y. E. (2017). Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk. Proceedings of the National Academy of Sciences of the United States of America, 114(23), E4564–E4573. https://doi.org/10.1073/pnas.1620149114

Liu, S., Jiao, J., Lu, T. J., Xu, F., Pickard, B. G., & Genin, G. M. (2017). Arabidopsis leaf trichomes as acoustic antennae. Biophysical Journal, 113(9), 2068–2076. https://doi.org/10.1016/j.bpj.2017.07.035

Melo, A. M., Elbaum-Garfinkle, S., & Rhoades, E. (2017). Insights into tau function and dysfunction through single-molecule fluorescence. Methods in Cell Biology, 141, 27–44. https://doi.org/10.1016/bs.mcb.2017.06.010

Mugnai, M. L., & Thirumalai, D. (2017). Kinematics of the lever arm swing in myosin VI. Proceedings of the National Academy of Sciences of the United States of America, 114(22), E4389–E4398. https://doi.org/10.1073/pnas.1615708114

Polacheck, W. J., Kutys, M. L., Yang, J., Eyckmans, J., Wu, Y., Vasavada, H., Hirschi, K. K., & Chen, C. S. (2017). A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature, 552(7684), 258–262.

Poleshko, A., Shah, P. P., Gupta, M., Babu, A., Morley, M. P., Manderfield, L. J., Ifkovits, J. L., Calderon, D., Aghajanian, H., Sierra-Pagán, J. E., Sun, Z., Wang, Q., Li, L., Dubois, N. C., Morrisey, E. E., Lazar, M. A., Smith, C. L., Epstein, J. A., & Jain, R. (2017). Genome-nuclear lamina interactions regulate cardiac stem cell lineage restriction. Cell, 171(3), 573-587.e14. https://doi.org/10.1016/j.cell.2017.09.018

Pyrpassopoulos, S., Shuman, H., & Ostap, E.M. (2017). Adhesion force and attachment lifetime of the kif16b-px domain interaction with lipid membranes. Molecular Biology of the Cell, 28(23), 3315–3322. https://doi.org/10.1091/mbc.E17-05-0324

Rosales, A. M., Vega, S. L., DelRio, F. W., Burdick, J. A., & Anseth, K. S. (2017). Hydrogels with reversible mechanics to probe dynamic cell microenvironments. Angewandte Chemie International Edition, 56(40), 12132–12136. https://doi.org/10.1002/anie.201705684

Shutova, M. S., Asokan, S. B., Talwar, S., Assoian, R. K., Bear, J. E., & Svitkina, T. M. (2017). Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility. Journal of Cell Biology, 216(9), 2877–2889. https://doi.org/10.1083/jcb.201705167

Spencer, T. M., Blumenstein, R. F., Pryse, K. M., Lee, S. L., Glaubke, D. A., Carlson, B. E., Elson, E. L., & Genin, G. M. (2017). Fibroblasts slow conduction velocity in a reconstituted tissue model of fibrotic cardiomyopathy. ACS Biomaterials Science and Engineering, 3(11), 3022–3028. https://doi.org/10.1021/acsbiomaterials.6b00576

Tutwiler, V., Wang, H., Litvinov, R. I., Weisel, J. W., & Shenoy, V. B. (2017). Interplay of platelet contractility and elasticity of fibrin/erythrocytes in blood clot retraction. Biophysical Journal, 112(4), 714–723. https://doi.org/10.1016/j.bpj.2017.01.005

Wang, X., & Carlsson, A. E. (2017). A master equation approach to actin polymerization applied to endocytosis in yeast. PLoS Computational Biology, 13(12), e1005901. https://doi.org/10.1371/journal.pcbi.1005901

Yeh, Y. C., Corbin, E. A., Caliari, S. R., Ouyang, L., Vega, S. L., Truitt, R., Han, L., Margulies, K. B., & Burdick, J. A. (2017). Mechanically dynamic PDMS substrates to investigate changing cell environments. Biomaterials, 145, 23–32. https://doi.org/10.1016/j.biomaterials.2017.08.033

CEMB Faculty Publications 2016

Hall, M. S., Alisafaei, F., Ban, E., Feng, X., Hui, C. Y., Shenoy, V. B., & Wu, M. (2016). Fibrous nonlinear elasticity enables positive Mechanical feedback between cells and ECMs. Proceedings of the National Academy of Sciences of the United States of America, 113(49), 14043–14048. https://doi.org/10.1073/pnas.1613058113