Publications

CEMB Faculty Publications 2018

 

Babaei, B., Velasquez-Mao, A.J., Pryse, K.M., McConnaughey, W.B., Elson, E.L. and Genin, G.M., 2018. Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix. Journal of the mechanical behavior of biomedical materials84, pp.198-207. DOI: doi.org/10.1016/j.jmbbm.2018.05.011

Bade ND, Xu T, Kamien RD, Assoian RK, Stebe KJ. 2018. Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration. Biophys J. 27;114(6):1467-1476. DOI:  doi.org/10.1016/j.bpj.2018.01.039

Ban, E., M. Franklin, S. Nam, L. Smith, H. Wang, R. Wells, O. Chaudhuri, J. Liphardt, and V. Shenoy. 2018.
Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. 2018. Biophysical Journal, 114(2):450-461. DOI:  10.1016/j.bpj.2017.11.3739

Benias, P.C., Wells, R.G., Sackey-Aboagye, B., Klavan, H., Reidy, J,. Buonocore, D,, Miranda, M., Wayne, M., Carr-Locke, D.L., and Theise, N.D. (2018) Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific Reports, 8(1), pp. 4947. DOI:    doi.org/10.1038/s41598-018-23062-6

Caporizzo, M.A., Chen, C.Y., Salomon, A.K., Bedi, K., Margulies, K.B. and Prosser, B., 2018. Microtubules provide a viscoelastic resistance to myocyte motion. bioRxiv, p.361824.

Cao, X., E. Ban, B. M. Baker, Y. Lin, J. A. Burdick, C. S. Chen, and V. B. Shenoy. 2018.  A Multi-scale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices.  Proceedings of The National Academy of Sciences, 114(23): E4549–E4555. DOI:  doi.org/10.1073/pnas.1620486114

 Carlsson, A.E., 2018. Membrane bending by actin polymerization. Current opinion in cell biology50, pp.1-7. DOI:10.1016/j.ceb.2017.11.007

Charrier, E. E., Pogoda, K., Wells, R. G. & Janmey, P. A. 2018. Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nat Commun, 9, 449.  DOI:  doi.org/10.1038/s41467-018-02906-9

Chen, C.Y., Caporizzo, M.A., Bedi, K., Vite, A., Bogush, A.I., Robison, P., Heffler, J.G., Salomon, A.K., Kelly, N.A., Babu, A. and Morley, M.P., Margulies, K.B., and Prosser, B.L. 2018. Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine, p.1.  DOI:10.1038/s41591-018-0046-2

Ganguly A, DeMott L, Zhu C, McClosky, DD, Anderson, CT and Dixit R. 2018, Importin-β directly regulates the motor activity and turnover of a kinesin-4. Developmental Cell, vol. 44, pp. 642-651.  DOI:10.1016/j.devcel.2018.01.027

Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A. & Shenoy, V. B. 2018. Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates. Proc Natl Acad Sci U S A, 115, E2686-E2695. DOI:   doi.org/10.1073/pnas.1716620115

Heo SJ, Cosgrove BD, Dai EN, Mauck RL. 2018. Mechano-adaptation of the stem cell nucleus. Nucleus.  Jan 1;9(1):9-19. doi: 10.1080/19491034.2017.1371398

Holle, A. W., Young, J. L., Van Vliet, K. J., Kamm, R. D., Discher, D., Janmey, P., Spatz, J. P. & Saif, T. 2018. Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Lett, 18, 1-8.  DOI: 10.1021/acs.nanolett.7b04982

Linderman, S.W., Golman, M., Gardner, T.R., Birman, V., Levine, W.N., Genin, G.M. and Thomopoulos, S., 2018. Enhanced tendon-to-bone repair through adhesive films. To appear in Acta Biomaterialia.

 Mcintosh, B. B., Pyrpassopoulos, S., Holzbaur, E. L. F. & Ostap, E. M. 2018. Opposing Kinesin and Myosin-I Motors Drive Membrane Deformation and Tubulation along Engineered Cytoskeletal Networks. Curr Biol, 28, 236-248 e5.

Mentes, A., Huehn, A., Liu, X., Zwolak, A., Dominguez, R., Shuman, H., Ostap, E. M. & Sindelar, C. V. 2018. High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. Proc Natl Acad Sci U S A, 115, 1292-1297.

Nebenführ A and Dixit R. 2018, Kinesins and Myosins: molecular motors that coordinate cellular functions in plants. Annual Review of Plant Biology, vol. 69, pp. 329-361. DOI:10.1146/annurev-arplant-042817-040024

Paek, J., Q. Lu, K.T. Park, S.E. Park, M. Cho, J.W. Song, H.I. Edelstein, W. Yang, J. Ishibashi, D. Stambolian, P. Seale, D. Huh, Microphysiological engineering self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues, submitted.  Nature Biomedical Engineering

Pogoda, K. & Janmey, P. A. 2018. Glial Tissue Mechanics and Mechanosensing by Glial Cells. Front Cell Neurosci, 12, 25. DOI:   doi.org/10.3389/fncel.2018.00025

Poleshko, A., Shah, P.P., Gupta, M., Babu, A., Morley, M., Manderfield, L.J., Ifkovits, J.L., Calderon, D., Aghajanian, H., Pagan, J.S.P., Sun, Z., Wang, Q, Li, L., Dubois, N., Morrisey, E.E., Lazar, M.A., Smith, C.L., Epstein, J.A., Jain, R. 2017. Genome-nuclear lamina interactions regulate progenitor cell lineage restriction during cardiogenesis. Cell. Oct 19;171(3):573-587.e14.  DOI: 10.1016/j.cell.2017.09.018

Powers, SK, AS Holehouse, DA Korasick, KH Schreiber, E Tycksen, JM Jez, RV Pappu, and L.C. Strader. 2018.  Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thalianaCell, in revision.

Qu, F., Q. Li, X. Wang, X. Cao, M. H. Zgonis, J. L. Esterhai, V. B. Shenoy, and R. L. Mauck. 2018.
Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues.
Scientific Reports, 8:3295.  DOI: 10.1038/s41598-018-21212-4

Seo, J., W.Y. Byun, F. Alisafaei, A. Georgescu, M. Massaro-Giordano, V.B. Shenoy, V. Lee, V. Bunya, D. Huh, Multiscale reverse engineering of the human ocular surface, under revision in Nat. Med. 2018

Song, K.H., C.B. Highley, A. Rouff, J.A. Burdick, 2018. Complex 3D-printed Microchannels within Cell-degradable Hydrogels, Advanced Functional Materials, in press.

Song, J., J. Paek, K.T. Park, J. Seo, D. Huh, 2018. A bioinspired microfluidic model of mucus plug-induced airway injury,  Biomicrofluidics 2018, 12(4):042211 (Editor’s pick). DOI: 10.1063/1.5027385

Vega, S.L., M.Y. Kwon, K.H. Song, C. Wang, R.L. Mauck, L. Han, J.A. Burdick, 2018.Combinatorial Hydrogels with Biochemical Gradients for Screening 3D Cellular Microenvironments, Nature Communications, 9:614, DOI: 10.1038/s41467-018-03021-5

Wang, C., Clark, A., Yan, Z., Kong, B. and Cheng, X., 2018. Fabrication and characterization of magnetic-vortex microdiscs for applying force in mechanobiological systems. Bulletin of the American Physical Society.

Woody, M S., Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap. 2018. Positive Cardiac Inotrope, Omecamtiv Mecarbil, Activates Muscle Despite Suppressing the Myosin Working Stroke. Under review at Nature Communications.

 Wu, S., Chen, M.S., Maurel, P., Lee, Y.S., Bunge, M. and Arinzeh, T.L., 2018. Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro. Journal of Neural Engineering. DOI: 10.1088/1741-2552/aac77f.

Xin Chen, Moxiao Li, Mao Yang, Shaobao Liu, Guy M. Genin, Feng Xu, Tian Jian Lu. The elastic fields of a compressible liquid inclusion. To appear in Extreme Mechanics Letters.

Yu CK, Xu T, Assoian RK, Rader DJ. 2018. Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators. Arterioscler Thromb Vasc Biol. 38(1):164-173.  DOI: 10.1161/ATVBAHA.117.310237. PMC5881588

CEMB Faculty Publications 2017

 

Ahmadzadeh,H.,  M. R. Webster, R. Behera, A. M. Jimenez Valencia, D. Wirtz, A. T. Weeraratna, and V. B. Shenoy (2017). Modeling the Two-way Feedback Between Contractility and Matrix Realignment Reveals a Non-linear Mode of Cancer Cell Invasion.  Proceedings of The National Academy Of Sciences, 114(9): E1617-E1626.
DOI: 10.1073/pnas.1617037114

Babaei, B., Velasquez-Mao, A.J., Thomopoulos, S., Elson, E.L., Abramowitch, S.D. and Genin, G.M., 2017. Discrete quasi-linear viscoelastic damping analysis of connective tissues, and the biomechanics of stretching. Journal of the Mechanical Behavior of Biomedical Materials. 69, 193-202.
DOI: 10.1016/j.jmbbm.2016.12.013

Basu, D. and E. S. Haswell. (2017). Plant Mechanosensitive Ion Channels: An Ocean of Possibilities. Current Opinion in Plant Biology, 40:43-48.
DOI:10.1016/j.pbi.2017.07.002

Cao, X., E. Ban, B. M. Baker, Y. Lin, J. A. Burdick, C. S. Chen, and V. B. Shenoy. (2017), A Multi-scale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices.  Proceedings of The National Academy of Sciences, 114(23): E4549–E4555.
DOI:10.1073/pnas.1620486114

Charrier, E. E., Pogoda, K., Wells, R. G. & Janmey, P. A. 2017. Control of cell morphology, stiffness, and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nature Communications, in revision.

Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G.M., Deshpande, V.S., Lu, T.J. and Xu, F., 2017. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews.
DOI: 10.1016/j.plrev.2017.06.016

Damaraju, S, Shen, Y, Elele, E, Khusid, B, Eshghinejad, A., Li, J., Jaffe, M., Livingston Arinzeh, T.  “Three-Dimensional Piezoelectric Fibrous Scaffolds Selectively Promote Mesenchymal Stem Cell Differentiation”. Biomaterials, 2017 (accepted).

Ganguly, A., DeMott, L. and Dixit, R., 2017. The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly. J Cell Sci, 130(7), pp.1232-1238.
DOI: 10.1242/jcs.196857

Guoyou Huang, Fei Li, Xin Zhao, Yufei Ma, Yuhui Li, Min Lin, Guorui Jin, Tian Jian Lu, Guy M. Genin, Feng XuFunctional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment. (Accepted.  To appear in Chemical Reviews)

Hamant, O. and E. S. Haswell. (2017). Life Behind the Wall: Sensing Mechanical Cues in Plants. BMC Biology, 15:59.
DOI: 10.1186/s12915-017-0403-5

Jiang, Y., K.M. Pryse, A. Melnykov, G.M. Genin, E.L. Elson, 2017.  Investigation of Nanoscopic Phase Separations in Lipid Membranes Using Inverse FCS. (To appear in Biophysical Journal).

Hall, M.S.,  F. Alisafaei, E. Ban, X. Feng, C. Y. Hui, V. B. Shenoy, and M. Wu. (2016). Fibrous nonlinear elasticity enables positive mechanical feedback between cells and extracellular matrices.  Proceedings Of The National Academy Of Sciences, 113(49): 14043–14048.

Lippert LG, Dadosh T, Hadden JA, Karnawat V, Diroll BT, Murray CB, Holzbaur ELF, Schulten K, Reck-Peterson SL, Goldman YE. (2017). Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.Proceedings Of The National Academy Of Sciences U S A. Jun 6;114(23):E4564-E4573.
DOI: 10.1073/pnas.1620149114

Lin, M., Liu, S.B., Genin, G.M., Zhu, Y., Shi, M., Ji, C., Li, A., Lu, T.J. and Xu, F., 2017. Melting Away Pain: Decay of Thermal Nociceptor Transduction during Heat-Induced Irreversible Desensitization of Ion Channels. ACS Biomaterials Science & Engineering.
DOI: 10.1021/acsbiomaterials.6b00789

Lipner, J., Boyle, J.J., Xia, Y., Birman, V., Genin, G.M. and Thomopoulos, S., 2017. Toughening of fibrous scaffolds by mobile mineral deposits. Acta Biomaterialia.
DOI: 10.1016/j.actbio.2017.05.033

Liu, S.B.,  J.J. Jiao, T.J. Lu, F. Xu, B.G. Pickard, and G.M. Genin. Arabidopsis Leaf Trichomes as Acoustic Antennae. (Accepted. To appear in Biophysical Journal, 2017).

Melo, A.M., Elbaum-Garfinkle, S., and Rhoades, E. (2017). Insights into tau function and dysfunction through single-molecule fluorescence. Methods in Cell Biology 141, 27-44.
DOI: 10.1016/bs.mcb.2017.06.010

Poleshko, A., Gupta, M., Shah, P.P., Babu, A., Morley, M., Manderfield, L.J., Ifkovits, J.L., Calderon, D., Aghajanian, H., Pagan, J.S.P., Sun, Z., Wang, Q,, Li, L., Dubois, N., Morrisey, E.E., Lazar, M.A., Smith, C.L., Epstein, J.A., and Jain, R. Genome-nuclear lamina interactions regulate progenitor cell lineage restriction during cardiogenesis. Cell, October 19 2017.
DOI: 10.1016/j.cell.2017.09.018

Pyrpassopoulos, I., Shuman, H. & Ostap, E. M. 2017. Adhesion Force and Attachment Lifetime of the KIF16B-PX Domain Interaction with Lipid Membranes. Mol. Biol. Cell, In Press.

Rosales, A., Vega, S., DelRio, F., Burdick, J., and Anseth, K. Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments. Angewandte Chemie, in press.
DOI: 10.1002/anie.201705684

Spencer, Teresa M., Ryan F. Blumenstein, Kenneth M. Pryse, Sheng-Lin Lee, David A. Glaubke, Brian E. Carlson, Elliot L. Elson, and Guy M. Genin. (2017). Fibroblasts Slow Conduction Velocity in a Reconstituted Tissue Model of Fibrotic Cardiomyopathy. ACS Biomaterials Science & Engineering.
DOI: 10.1021/acsbiomaterials.6b00576

Shutova MS, Asokan SB, Talwar S, Assoian RK, Bear JE, Svitkina TM (2017).  Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility. J Cell Biol. 216:2877-2889.
DOI: 10.1083/jcb.201705167

Tutwiler, V.,  H. Wang, R. I. Litvinov, J. W. Weisel, and V. B. Shenoy (2017).  Interplay of Platelet Contractility and Elasticity of Fibrin/Erythrocytes in Blood Clot Retraction. Biophysical Journal, 112(4):714-723 FEBRUARY.
DOI: 10.1016/j.bpj.2017.01.005

Yeh, Y., Corbin, E., Caliari, S., Ouyang, L., Vega, S., Truitt, R., Han, L., Margulies, K., and Burdick, J. (2017). Mechanically Dynamic PDMS Substrates to Investigate Changing Cell Environments. Biomaterials, 145, 23-32.
DOI: 10.1016/j.biomaterials.2017.08.033