Publications

CEMB Faculty Publications 2019

Avgoulas EI, Sutcliffe MPF, Linderman SW, Birman V, Thomopoulos S, Genin GM. 2019 Adhesive-based tendon-to- bone repair: failure modelling and materials selection. J. R. Soc. Interface 16: 20180838. https://doi.org/10.1098/rsif.2018.0838, PMCID: pending

Ban E, Wang H, Franklin JM, Liphardt JT, Janmey PA and Shenoy VB, (2019) Strong triaxial coupling and anomalous Poisson effect in collagen networks, Proc Natl Acad Sci U S A, 116: 6790-6799. DOI: 10.1073/pnas.1815659116.

Boyle JJ, Soepriatn A, Damen F, Rowe RA, Pless RB, Kovacs A, Goergen CJ, Thomopoulos S, and Genin GM. 2019. Regularization-Free Strain Mapping in Three Dimensions, With Application to Cardiac Ultrasound. ASME Journal of Biomechanical Engineering, 141(1), p.011010.  https://doi.org/10.1115/1.4041576, PMCID: PMC6298532

Brankovic S, Hawthorne EA, Yu X, Zhang Y, Assoian RK. 2019. MMP12 preferentially attenuates axial stiffening of aging arteries. J Biomech Eng. Mar 27. doi: 10.1115/1.4043322. [Epub ahead of print] PubMed PMID: 30917195.

Burkart G and Dixit R.  2019. Microtubule bundling by MAP65-1 protects against severing by inhibiting the binding of katanin. Molecular Biology of the Cell, 30: 1587-1597. doi 10.1091.mbc.E18-12-0776

Chen X, He W, Liu S, Li M. Genin GM, Xu F, and Lu TJ. 2019.  Volumetric response of an ellipsoidal liquid inclusion: implications for cell mechanobiology. Acta Mechanica Sinica (2019) 35(2):338–342. https://doi.org/10.1007/s10409-019-00850-5, PMCID: pending

Chen X, Li M, Liu S, Liu F, Genin GM, Xu F, and Lu TJ. 2019. Translation of a coated rigid spherical inclusion in an elastic matrix: exact solution, and implications for mechanobiology. Journal of Applied Mechanics, 86(5), p.051002. https://doi.org/10.1115/1.4042575, PMCID: pending

Cho S, Majkut S, Vashisth M, Abbas A, Xia Y, Vogel K, Ivanovska I, Irianto J, Tewari M, Tang HY, Prosser B, and Discher DE.  “Mechanosensing to protect the genome from DNA damage in development.”  Developmental Cell, accepted for publication March 2019.

Corbin EA, Vite A, Peyster E, Bhoopalam M, Brandimarto J, Wang X, Bennett A, Clark A, Cheng X, Turner K, Musunuru K, and Margulies KB. 2019. Tunable and reversible substrate stiffness reveals a dynamic mechanosensitivity of cardiomyocytes. ACS Applied Materials & Interfaces, 11 (23), 20603-20614. .  DOI: 10.1021/acsami.9b02446.

Davidson MD, Song KH, Lee MH, Llewellyn J, Du Y, Baker BM, Wells RG, Burdick JA, Engineered Fibrous Networks to Investigate the Influence of Fiber Mechanics on Myofibroblast Differentiation, ACS Biomaterials Science & Engineering, in press.  DOI: 10.1021/acsbiomaterials.8b01276

Del Campo L, Sánchez-López A, Salaices M, von Kleeck RA, Expósito E, González-Gómez C, Cussó L, Guzmán-Martínez G, Ruiz-Cabello J, Desco M, Assoian RK, Briones AM, Andrés V. 2019. Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite. Aging Cell. Mar 18:e12936. doi: 10.1111/acel.12936. [Epub ahead of print] PubMed PMID: 30884114.

Discher D.E. 2019. Biomembrane mechanical properties direct diverse cell functions. pgs. 263-285 in Physics of Biological Membranes, Bassereau P., and Sens P. (eds). Springer-Verlag, Berlin (2 volumes). DOI: 10.1007/978-3-030-00630-3_11

Du Y, Khandekar G, Llewellyn J, Polacheck WJ, Chen CSWells RG. A Bile Duct-on-a-Chip with Organ-Level Functions. Hepatology.  doi:  10.1002/hep.30918

Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE. 2019.  Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Proc Natl Acad Sci U S A. Feb 19. pii: 201813952. doi: 10.1073/pnas.1813952116. [Epub ahead of print] PubMed PMID: 30782824; PubMed Central PMCID: PMC6410851.

Highley CB, Song KH, Daly AC, Burdick JA. 2019. Jammed Microgel Inks for 3D Printing Applications, Advanced Science, 6:1801076.  DOI: 10.1002/advs.201801076

Huang H and Dean D, 3-D Printed Cellulose Acetate Tissue Scaffolds, submitted to Additive Manufacturing, 2019.

Huang G, Xu F, Genin GM, and Lu TJ. 2019. Mechanical microenvironments of living cells: a critical frontier in mechanobiology. Acta Mechanica Sinica, 35(2), pp.265-269. https://doi.org/10.1007/s10409-019-00854-1, PMCID: pending

Ji S, Almeida E, Guvendiren M, 2019, 3D bioprinting of complex channels within cell-laden hydrogels, Acta Biomaterialia, doi: 10.1016/j.actbio.2019.02.038.

Jiang S, Lyu C, Zhao P, Li W, Kong W, Huang C, Genin GM, and Du Y. 2019. Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D. Nature Communications, 10(1), pp.1-14. https://doi.org/10.1038/s41467-019-11397-1, PMCID: pending

Jiang Y, Pryse K, Singamaneni S, Genin GM, and Elson EL. 2019. Atomic force microscopy of phase separation on ruptured, giant unilamellar vesicles, and a mechanical pathway for the co-existence of lipid gel phases. Journal of biomechanical engineering. https://doi.org/10.1115/1.4043871, PMCID: pending

Jing, H and LC Strader (2019)  Interplay of auxin and cytokinin in lateral root development.  International Journal of Molecular Sciences, 20:486.  doi.org/10.3390/ijms20030486

Joshi H, Morley SC, 2019. Cells under stress: The mechanical environment shapes inflammasome responses to danger signals, Journal of Leukocyte Biology (In press)  doi: 10.1002/JLB.3MIR1118-417R

Kaur A, Ecker BL, Douglass SM, Kugel III CH, Webster MR, Almeida F, Somasundaram R, Hayden J, Ban E, Ahmadzadeh H, Franco-Barraza J, Shah N, Mellis I, Keeney F, Kossenkov AV, Tang HY, Yin X, Liu Q, Xu X, Fane M, Brafford P, Herlyn M, Speicher DW, Wargo J, Tetzlaff M, Haydu L, Raj A, Shenoy VB, Cukierman E, and Weeraratna AT (2019). Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. CANCER DISCOVERY, 9(1): 64-81. DOI: 10.1158/2159-8290.CD-18-0193

Kieckhaefer JE, Maina F, Wells RG, Wangensteen K. 2019. Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and Crispr/Cas9. Semin Liver Dis; epub ahead of print; doi: 10.1055/s-0039-1678725.

Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK. 2019. Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI Insight. Jan 10;4(1). pii: 122742. doi: 10.1172/jci.insight.122742. [Epub ahead of print] PubMed PMID: 30626744.

Liu S, Tao R, Wang M, Tian J, Genin GM, Lu TJ, and Xu F, 2019. Regulation of cell behavior by hydrostatic pressure. Applied Mechanics Reviews, 71(4), p.040803. doi:  10.1115/1.4043947. PMCID: pending

Loebel C, Mauck RL, Burdick JA. 2019. Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels. Nat Mater. Mar 18. doi: 10.1038/s41563-019-0307-6. [Epub ahead of print]. PMID: 30886401

Ma S, Zhu M, Xia X, Guo L, Genin GM, Sacks MS, Gao M, Mutic S, Hu Y, Hu CH, and Feng Y. 2019. A preliminary study of the local biomechanical environment of liver tumors in vivo. Medical physics, 46(4), pp.1728-1739. https://doi.org/10.1002/mp.13434  PMID: 30730058

Mandal K, Raz-Ben Aroush D, Graber ZT, Wu B, Park CY, Fredberg JJ, Guo W, Baumgart T and Janmey PA, (2019) Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force, ACS Nano, 13: 203-214. DOI: 10.1021/acsnano.8b05286.

Mason DE, Collins JM, Dawahare, JH, Nguyen TD, Lin Y, Voytik-Harbin SL, Zorlutuna PZ, Yoder ME, Boerckel JD. 2019. “YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility.” Journal of Cell Biology. Apr 1;218(4):1369-1389. doi.org/10.1083/jcb.201806065.

Menezes R, Hashemi S, Vincent R, Collins G, Meyer J, Foston MArinzeh TL. 2019. Investigation of glycosaminoglycan mimetic scaffolds for neurite growth. Acta Biomaterialia. doi: 10.1016/j.actbio.2019.03.024 .

Michniewicz, M, C-H Ho, TA Enders, E Floro, LK Gunther, SK Powers, EM Frick, CN Topp, WB Frommer, and LC Strader (2019)  TRANSPORTER OF IBA1 links auxin and cytokinin to regulate root architecture.  Developmental Cell.  50:1-11.   doi.org/10.2139/ssrn.3339905

Motahari F and Carlsson AE. 2019. Thermodynamically consistent treatment of the growth of a biopolymer in the presence of a smooth obstacle interaction potential.  Phys. Rev. E (accepted for publication, October 2019). Abstract.

Paek J, Lu Q, Park QT, Park SE, Cho M, JW Song, HI Edelstein, Yang W, Ishibashi J, Stambolian D, Seale P, Huh D, “Microphysiological engineering self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues,” ACS Nano 2019, accepted for publication.

Pakshir P, Alizadehgiashi M, Wong B, Coelho NM, Chen X, Gong Z, Shenoy VB, McCulloch C and Hinz B. (2019). Dynamic Fibroblast Contractions Attract Remote Macrophages in Fibrillar Collagen Matrix. NATURE COMMUNICATIONS, IN PRESS. DOI: not yet available

Polacheck WJ, Kutys ML, Tefft JB, Chen CS. 2019. Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. Apr 5. doi: 10.1038/s41596-019-0144-8.  PMID:30953042

Powers, SK, AS Holehouse, DA Korasick, KH Schreiber, E Tycksen, JM Jez, RV Pappu, and LC Strader (2019)  Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana. Molecular Cell 76:1-14.  doi.org/10.1016/j.molcel.2019.06.044.

Roell GW, Carr R, Campbell T, Shang Z, Henson W, Czajka J, Martín HG, Zhang F, Foston M, Dantas G, Moon T, Tang Y. 2019. A concerted systems biology analysis of phenol metabolism in Rhodococcus opacus PD630. Metabolic Engineering, 55: 120-130.  doi.org/10.1016/j.ymben.2019.06.013.

Rowe R, Pryse KM, Elson EL, Genin GM. 2019. Stable fitting of noisy stress relaxation data. Mechanics of Soft Materials. https://doi.org/10.1007/s42558-019-0010-4 PMCID: pending

See K, Lan Y, Rhoades J, Jain R, Smith CL, Epstein JA. 2019. Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains. Development. Feb 5;146(3). pii: dev174078. doi: 10.1242/dev.174078. PubMed PMID: 30723106; PubMed Central PMCID: PMC6382005.

Seo J, Byun WY, Alisafaei F, Georgescu A, Massaro-Giordano M, Shenoy VB, Lee V, Bunya V and Huh D (2019). Multiscale Reverse Engineering of the Human Ocular Surface. NATURE MEDICINE, 25:1310–1318. doi: 10.1038/s41591-019-0531-2

van Oosten A, Chen X, Chin L, Cruz K, Patteson AE, Pogoda K, Shenoy VB, Janmey PA (2019). The Emergence of Tissue Mechanics from Confinement of Non-linear Biopolymer Networks by Densely Packed Cells. NATURE, IN PRESS. DOI: not yet available

Xia Y, Cho S, Vashisth M, Ivanovska IL, Dingal PCDP, Discher DE. 2019. Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods DOI: 10.1016/j.ymeth.2018.12.009

Xia Y, Pfeifer C, Discher DE. 2019. Nuclear mechanics during constricted migration. Acta Mechanica Sinica. DOI: 10.1007/s10409-018-00836-9

Zhou D, Hao J, Clark A, Kim KH, Zhu L, Liu J, Cheng X, and Li B. 2019.  Sono-assisted surface energy driven assembly of 2D materials on flexible polymer substrates: A green assembly method using water.  Applied Materials & Interfaces, 11, 36, 33458-33464  DOI: 10.1021/acsami.9b10469

CEMB Faculty Publications 2018

Babaei, B., Velasquez-Mao, A.J., Pryse, K.M., McConnaughey, W.B., Elson, E.L. and Genin, G.M., 2018. Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix. Journal of the mechanical behavior of biomedical materials84, pp.198-207. DOI: doi.org/10.1016/j.jmbbm.2018.05.011

Bade ND, Kamien RD, Assoian RK, Stebe KJ. 2018. Edges impose planar alignment in nematic monolayers by directing cell elongation and enhancing migration. Soft Matter. 2018 Sep 7;14(33):6867-6874. doi: 10.1039/c8sm00612a. Epub 2018 Aug 6. PubMed PMID: 30079410.

Bade ND, Xu T, Kamien RD, Assoian RK, and Stebe KJ. 2018. Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration. Biophys J. 27;114(6):1467-1476. DOI:  doi.org/10.1016/j.bpj.2018.01.039

Ban, E., M. Franklin, S. Nam, L. Smith, H. Wang, R. Wells, O. Chaudhuri, J. Liphardt, and V. Shenoy. 2018.
Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. 2018. Biophysical Journal, 114(2):450-461. DOI:  10.1016/j.bpj.2017.11.3739

Benias, P.C., Wells, R.G., Sackey-Aboagye, B., Klavan, H., Reidy, J,. Buonocore, D,, Miranda, M., Wayne, M., Carr-Locke, D.L., and Theise, N.D. (2018) Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific Reports, 8(1), pp. 4947. DOI:    doi.org/10.1038/s41598-018-23062-6

Caporizzo, M.A., Chen, C.Y., Salomon, A.K., Bedi, K., Margulies, K.B. and Prosser, B., 2018. “Microtubules provide a viscoelastic resistance to myocyte motion.” Biophysical Journal 115 1-12 doi.org/10.1016/j.bpj.2018.09.019

Capporizzo, M.A., Fishman, C.E., Sato, O., Jamiolkowski, R.M., Ikebe, M., and Goldman, Y.E. 2018. The antiparallel dimerization of myosin X imparts bundle selectivity for processive motility. Biophys. J., 114:1400-1410.

Cao, X., E. Ban, B. M. Baker, Y. Lin, J. A. Burdick, C. S. Chen, and V. B. Shenoy. 2018.  A Multi-scale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices.  Proceedings of The National Academy of Sciences, 114(23): E4549–E4555. DOI:  doi.org/10.1073/pnas.1620486114

 Carlsson, A.E., 2018. Membrane bending by actin polymerization. Current opinion in cell biology50, pp.1-7. DOI:10.1016/j.ceb.2017.11.007

Charrier, E. E., Pogoda, K., Wells, R. G. & Janmey, P. A. 2018. Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nat Commun, 9, 449.  DOI:  doi.org/10.1038/s41467-018-02906-9

Chen, C.Y., Caporizzo, M.A., Bedi, K., Vite, A., Bogush, A.I., Robison, P., Heffler, J.G., Salomon, A.K., Kelly, N.A., Babu, A. and Morley, M.P., Margulies, K.B., and Prosser, B.L. 2018. Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine, p.1.  DOI:10.1038/s41591-018-0046-2

Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan AV, Jokhun DS, Shenoy VB, and Shivashankar GV (2018). Compressive Force Induces Reversible Chromatin Condensation and Cell Geometry Dependent Transcriptional Response. MOLECULAR BIOLOGY OF THE CELL, 29(25): 3039-3051. DOI:1091/mbc.E18-04-0256

Fan Y, Burkart GM, and Dixit R.  2018. The Arabidopsis SPIRAL2 protein targets and stabilizes microtubule minus-ends. Current Biology, 28: 987-994.doi.org/10.1016/j.cub.2018.02.014.

Freedman BR, Rodriguez AB, Leiphart RJ, Newton JB, Ban E, Sarver JJ, Mauck RL, Shenoy VB, Soslowsky LJ. 2018. Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission, Sci Rep. 2018 Jul 18;8(1):10854. doi: 10.1038/s41598-018-29060-y.  PMID: 30022076

Ganguly A, DeMott L, Zhu C, McClosky, DD, Anderson, CT and Dixit R. 2018, Importin-β directly regulates the motor activity and turnover of a kinesin-4. Developmental Cell, vol. 44, pp. 642-651.  DOI:10.1016/j.devcel.2018.01.027

Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A. & Shenoy, V. B. 2018. Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates. Proc Natl Acad Sci U S A, 115, E2686-E2695. DOI:   doi.org/10.1073/pnas.1716620115

Haswell ES and Dixit R (2018). Counting What Counts: The Importance of Quantitative Approaches to Studying Plant Cell Biology. Current Opinion in Plant Biology, 46: 1-3.

Heo SJ, Cosgrove BD, Dai EN, Mauck RL. 2018. Mechano-adaptation of the stem cell nucleus. Nucleus.  Jan 1;9(1):9-19. doi: 10.1080/19491034.2017.1371398

Holle, A. W., Young, J. L., Van Vliet, K. J., Kamm, R. D., Discher, D., Janmey, P., Spatz, J. P. & Saif, T. 2018. Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Lett, 18, 1-8.  DOI: 10.1021/acs.nanolett.7b04982

Laidmae I, Erglis K, Cebers A, Janmey PA and Uibo R. (2018) Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation, J Mater Sci Mater Med, 29: 182. DOI: 10.1007/s10856-018-6192-8.

Lebreton G, Géminard C, Lapraz F, Pyrpassopoulos S, Cerezo D, Spéder P, Ostap EM, Noselli S. 2018. Molecular to organismal chirality is induced by the conserved myosin 1D. Science. Nov 23;362(6417):949-952. doi: 10.1126/science.aat8642. PubMed PMID: 30467170.

Leiphart RJ, Chen D, Peredo AP, Loneker AE and Janmey PA, (2018) Mechanosensing at Cellular Interfaces, Langmuir, DOI: 10.1021/acs.langmuir.8b02841.

Linderman, S.W., Golman, M., Gardner, T.R., Birman, V., Levine, W.N., Genin, G.M. and Thomopoulos, S., 2018. Enhanced tendon-to-bone repair through adhesive films. To appear in Acta Biomaterialia.

Malik R, Luong T, Cao X, Han B, Shah N, Han L, Shenoy VB, Lelkes PI, and Cukierman E. (2018). Rigidity Controls Human Desmoplastic Matrix Anisotropy to Enable Pancreatic Cancer Invasion via Extracellular Signal-Regulated Kinase 2. MATRIX BIOLOGY. DOI: 10.1016/j.matbio.2018.11.001

Mcintosh, B. B., Pyrpassopoulos, S., Holzbaur, E. L. F. & Ostap, E. M. 2018. Opposing Kinesin and Myosin-I Motors Drive Membrane Deformation and Tubulation along Engineered Cytoskeletal Networks. Curr Biol, 28, 236-248 e5.

Mentes, A., Huehn, A., Liu, X., Zwolak, A., Dominguez, R., Shuman, H., Ostap, E. M. & Sindelar, C. V. 2018. High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. Proc Natl Acad Sci U S A, 115, 1292-1297.

Meyer, J.R., Waghmode, S.B., He, J., Gao, Y., Hoole, D., da Costa Sousa, L., Balan, V. and Foston, M.B., 2018. Isolation of lignin from Ammonia Fiber Expansion (AFEX) pretreated biorefinery waste. Biomass and bioenergy, 119, pp.446-455 DOI:10.1016/j.biombioe.2018.09.017

Nebenführ A and Dixit R. 2018, Kinesins and Myosins: molecular motors that coordinate cellular functions in plants. Annual Review of Plant Biology, vol. 69, pp. 329-361. DOI:10.1146/annurev-arplant-042817-040024

Paek, J., Q. Lu, K.T. Park, S.E. Park, M. Cho, J.W. Song, H.I. Edelstein, W. Yang, J. Ishibashi, D. Stambolian, P. Seale, D. Huh, Microphysiological engineering self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues, submitted.  Nature Biomedical Engineering

Pogoda, K. & Janmey, P. A. 2018. Glial Tissue Mechanics and Mechanosensing by Glial Cells. Front Cell Neurosci, 12, 25. DOI:   doi.org/10.3389/fncel.2018.00025

Poleshko, A., Shah, P.P., Gupta, M., Babu, A., Morley, M., Manderfield, L.J., Ifkovits, J.L., Calderon, D., Aghajanian, H., Pagan, J.S.P., Sun, Z., Wang, Q, Li, L., Dubois, N., Morrisey, E.E., Lazar, M.A., Smith, C.L., Epstein, J.A., Jain, R. 2017. Genome-nuclear lamina interactions regulate progenitor cell lineage restriction during cardiogenesis. Cell. Oct 19;171(3):573-587.e14.  DOI: 10.1016/j.cell.2017.09.018

Powers, SK, AS Holehouse, DA Korasick, KH Schreiber, E Tycksen, JM Jez, RV Pappu, and L.C. Strader. 2018.  Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thalianaCell, in revision.

Qu, F., Q. Li, X. Wang, X. Cao, M. H. Zgonis, J. L. Esterhai, V. B. Shenoy, and R. L. Mauck. 2018.
Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues.
Scientific Reports, 8:3295.  DOI: 10.1038/s41598-018-21212-4

Rosales AM, Rodell CB, Chen MH, Morrow MG, Anseth KS, Burdick JA. 2018. Reversible Control of Network Properties in Azobenzene-Containing Hyaluronic Acid-Based Hydrogels, Bioconjugate Chemistry, 29:905-913. DOI: 10.1021/acs.bioconjchem.7b00802

Seo, J., W.Y. Byun, F. Alisafaei, A. Georgescu, M. Massaro-Giordano, V.B. Shenoy, V. Lee, V. Bunya, D. Huh, Multiscale reverse engineering of the human ocular surface, under revision in Nat. Med. 2018

Song, K.H., C.B. Highley, A. Rouff, J.A. Burdick, 2018. Complex 3D-printed Microchannels within Cell-degradable Hydrogels, Advanced Functional Materials, in press.

Song, J., J. Paek, K.T. Park, J. Seo, D. Huh, 2018. A bioinspired microfluidic model of mucus plug-induced airway injury,  Biomicrofluidics 2018, 12(4):042211 (Editor’s pick). DOI: 10.1063/1.5027385

Vega, S.L., M.Y. Kwon, K.H. Song, C. Wang, R.L. Mauck, L. Han, J.A. Burdick, 2018.Combinatorial Hydrogels with Biochemical Gradients for Screening 3D Cellular Microenvironments, Nature Communications, 9:614, DOI: 10.1038/s41467-018-03021-5

Wang, C., Clark, A., Yan, Z., Kong, B. and Cheng, X., 2018. Fabrication and characterization of magnetic-vortex microdiscs for applying force in mechanobiological systems. Bulletin of the American Physical Society.

Woody, M S., Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap. 2018. Positive Cardiac Inotrope, Omecamtiv Mecarbil, Activates Muscle Despite Suppressing the Myosin Working Stroke. Under review at Nature Communications.

Woody MS, Capitanio M, Ostap EM, Goldman YE. 2018. Electro-optic deflectors deliver advantages over acousto-optical deflectors in a high resolution, ultra-fast force-clamp optical trap. Opt Express. Apr 30;26(9):11181-11193. doi: 10.1364/OE.26.011181. PubMed PMID: 29716042; PubMed Central PMCID: PMC6005679.

Wu, S., Chen, M.S., Maurel, P., Lee, Y.S., Bunge, M. and Arinzeh, T.L., 2018. Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro. Journal of Neural Engineering. DOI: 10.1088/1741-2552/aac77f.

Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. 2018. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors Journal of Cell Biology 217: 3796-3808. doi: 10.1083/jcb.201711161

Xin Chen, Moxiao Li, Mao Yang, Shaobao Liu, Guy M. Genin, Feng Xu, Tian Jian Lu. The elastic fields of a compressible liquid inclusion. To appear in Extreme Mechanics Letters.

Yu CK, Xu T, Assoian RK, and Rader DJ. 2018. Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators. Arterioscler Thromb Vasc Biol. 38(1):164-173.  DOI: 10.1161/ATVBAHA.117.310237. PMC5881588

CEMB Faculty Publications 2017

Ahmadzadeh,H.,  M. R. Webster, R. Behera, A. M. Jimenez Valencia, D. Wirtz, A. T. Weeraratna, and V. B. Shenoy (2017). Modeling the Two-way Feedback Between Contractility and Matrix Realignment Reveals a Non-linear Mode of Cancer Cell Invasion.  Proceedings of The National Academy Of Sciences, 114(9): E1617-E1626.
DOI: 10.1073/pnas.1617037114

Babaei, B., Velasquez-Mao, A.J., Thomopoulos, S., Elson, E.L., Abramowitch, S.D. and Genin, G.M., 2017. Discrete quasi-linear viscoelastic damping analysis of connective tissues, and the biomechanics of stretching. Journal of the Mechanical Behavior of Biomedical Materials. 69, 193-202.
DOI: 10.1016/j.jmbbm.2016.12.013

Basu, D. and E. S. Haswell. (2017). Plant Mechanosensitive Ion Channels: An Ocean of Possibilities. Current Opinion in Plant Biology, 40:43-48.
DOI:10.1016/j.pbi.2017.07.002

Cao, X., E. Ban, B. M. Baker, Y. Lin, J. A. Burdick, C. S. Chen, and V. B. Shenoy. (2017), A Multi-scale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices.  Proceedings of The National Academy of Sciences, 114(23): E4549–E4555.
DOI:10.1073/pnas.1620486114

Charrier, E. E., Pogoda, K., Wells, R. G. & Janmey, P. A. 2017. Control of cell morphology, stiffness, and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nature Communications, in revision.

Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G.M., Deshpande, V.S., Lu, T.J. and Xu, F., 2017. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews.
DOI: 10.1016/j.plrev.2017.06.016

Damaraju, S, Shen, Y, Elele, E, Khusid, B, Eshghinejad, A., Li, J., Jaffe, M., Livingston Arinzeh, T.  “Three-Dimensional Piezoelectric Fibrous Scaffolds Selectively Promote Mesenchymal Stem Cell Differentiation”. Biomaterials, 2017 (accepted).

Ganguly, A., DeMott, L. and Dixit, R., 2017. The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly. J Cell Sci, 130(7), pp.1232-1238.
DOI: 10.1242/jcs.196857

Guoyou Huang, Fei Li, Xin Zhao, Yufei Ma, Yuhui Li, Min Lin, Guorui Jin, Tian Jian Lu, Guy M. Genin, Feng XuFunctional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment. (Accepted.  To appear in Chemical Reviews)

Hamant, O. and E. S. Haswell. (2017). Life Behind the Wall: Sensing Mechanical Cues in Plants. BMC Biology, 15:59.
DOI: 10.1186/s12915-017-0403-5

Jiang, Y., K.M. Pryse, A. Melnykov, G.M. Genin, E.L. Elson, 2017.  Investigation of Nanoscopic Phase Separations in Lipid Membranes Using Inverse FCS. (To appear in Biophysical Journal).

Hall, M.S.,  F. Alisafaei, E. Ban, X. Feng, C. Y. Hui, V. B. Shenoy, and M. Wu. (2016). Fibrous nonlinear elasticity enables positive mechanical feedback between cells and extracellular matrices.  Proceedings Of The National Academy Of Sciences, 113(49): 14043–14048.

Lippert LG, Dadosh T, Hadden JA, Karnawat V, Diroll BT, Murray CB, Holzbaur ELF, Schulten K, Reck-Peterson SL, Goldman YE. (2017). Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.Proceedings Of The National Academy Of Sciences U S A. Jun 6;114(23):E4564-E4573.
DOI: 10.1073/pnas.1620149114

Lin, M., Liu, S.B., Genin, G.M., Zhu, Y., Shi, M., Ji, C., Li, A., Lu, T.J. and Xu, F., 2017. Melting Away Pain: Decay of Thermal Nociceptor Transduction during Heat-Induced Irreversible Desensitization of Ion Channels. ACS Biomaterials Science & Engineering.
DOI: 10.1021/acsbiomaterials.6b00789

Lipner, J., Boyle, J.J., Xia, Y., Birman, V., Genin, G.M. and Thomopoulos, S., 2017. Toughening of fibrous scaffolds by mobile mineral deposits. Acta Biomaterialia.
DOI: 10.1016/j.actbio.2017.05.033

Liu, S.B.,  J.J. Jiao, T.J. Lu, F. Xu, B.G. Pickard, and G.M. Genin. Arabidopsis Leaf Trichomes as Acoustic Antennae. (Accepted. To appear in Biophysical Journal, 2017).

Melo, A.M., Elbaum-Garfinkle, S., and Rhoades, E. (2017). Insights into tau function and dysfunction through single-molecule fluorescence. Methods in Cell Biology 141, 27-44.
DOI: 10.1016/bs.mcb.2017.06.010

Poleshko, A., Gupta, M., Shah, P.P., Babu, A., Morley, M., Manderfield, L.J., Ifkovits, J.L., Calderon, D., Aghajanian, H., Pagan, J.S.P., Sun, Z., Wang, Q,, Li, L., Dubois, N., Morrisey, E.E., Lazar, M.A., Smith, C.L., Epstein, J.A., and Jain, R. Genome-nuclear lamina interactions regulate progenitor cell lineage restriction during cardiogenesis. Cell, October 19 2017.
DOI: 10.1016/j.cell.2017.09.018

Pyrpassopoulos, I., Shuman, H. & Ostap, E. M. 2017. Adhesion Force and Attachment Lifetime of the KIF16B-PX Domain Interaction with Lipid Membranes. Mol. Biol. Cell, In Press.

Rosales, A., Vega, S., DelRio, F., Burdick, J., and Anseth, K. Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments. Angewandte Chemie, in press.
DOI: 10.1002/anie.201705684

Spencer, Teresa M., Ryan F. Blumenstein, Kenneth M. Pryse, Sheng-Lin Lee, David A. Glaubke, Brian E. Carlson, Elliot L. Elson, and Guy M. Genin. (2017). Fibroblasts Slow Conduction Velocity in a Reconstituted Tissue Model of Fibrotic Cardiomyopathy. ACS Biomaterials Science & Engineering.
DOI: 10.1021/acsbiomaterials.6b00576

Shutova MS, Asokan SB, Talwar S, Assoian RK, Bear JE, Svitkina TM (2017).  Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility. J Cell Biol. 216:2877-2889.
DOI: 10.1083/jcb.201705167

Tutwiler, V.,  H. Wang, R. I. Litvinov, J. W. Weisel, and V. B. Shenoy (2017).  Interplay of Platelet Contractility and Elasticity of Fibrin/Erythrocytes in Blood Clot Retraction. Biophysical Journal, 112(4):714-723 FEBRUARY.
DOI: 10.1016/j.bpj.2017.01.005

Wang X and Carlsson AE.  2017.  A master equation approach to  actin polymerization applied to endocytosis in yeast. PLoS Computational Biology.  December 14; 13(12).  doi:  10.1371/journal.pcbi.1005901.

Yeh, Y., Corbin, E., Caliari, S., Ouyang, L., Vega, S., Truitt, R., Han, L., Margulies, K., and Burdick, J. (2017). Mechanically Dynamic PDMS Substrates to Investigate Changing Cell Environments. Biomaterials, 145, 23-32.
DOI: 10.1016/j.biomaterials.2017.08.033