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CEMB Faculty Publications

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Alisafaei, F., Jokhun, D. S., Shivashankar, G. V., & Shenoy, V. B. (2019). Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints. Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13200–13209. https://doi.org/10.1073/pnas.1902035116

Alisafaei, F., Jokhun, D. S., Shivashankar, G. V., & Shenoy, V. B. (2019). Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints. Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13200–13209. https://doi.org/10.1073/pnas.1902035116

Almeida, J., Mathur, J., Lee, Y. L., Sarker, B., & Pathak, A. (2023). Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality. Molecular Biology of the Cell. https://doi.org/10.1091/MBC.E22-10-0469

Almeida, J., Mathur, J., Lee, Y. L., Sarker, B., & Pathak, A. (2023). Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality. Molecular Biology of the Cellhttps://doi.org/10.1091/MBC.E22-10-0469

Cho, S., Vashisth, M., Abbas, A., Majkut, S., Vogel, K., Xia, Y., Ivanovska, I. L., Irianto, J., Tewari, M., Zhu, K., Tichy, E. D., Mourkioti, F., Tang, H. Y., Greenberg, R. A., Prosser, B. L., & Discher, D. E. (2019). Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell, 49(6), 920-935.e5. https://doi.org/10.1016/j.devcel.2019.04.020

Cho, S., Vashisth, M., Abbas, A., Majkut, S., Vogel, K., Xia, Y., Ivanovska, I. L., Irianto, J., Tewari, M., Zhu, K., Tichy, E. D., Mourkioti, F., Tang, H. Y., Greenberg, R. A., Prosser, B. L., & Discher, D. E. (2019). Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell, 49(6), 920-935.e5. https://doi.org/10.1016/j.devcel.2019.04.020

Cosgrove, B. D., Loebel, C., Driscoll, T. P., Tsinman, T. K., Dai, E. N., Heo, S.-J., Dyment, N. A., Burdick, J. A., & Mauck, R. L. (2021). Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments. Biomaterials, 270, 120662. https://doi.org/10.1016/j.biomaterials.2021.120662

Cosgrove, B. D., Loebel, C., Driscoll, T. P., Tsinman, T. K., Dai, E. N., Heo, S.-J., Dyment, N. A., Burdick, J. A., & Mauck, R. L. (2021). Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments. Biomaterials, 270, 120662. https://doi.org/10.1016/j.biomaterials.2021.120662

Gardini, L., Woody, M. S., Kashchuk, A. v., Goldman, Y. E., Ostap, E. M., & Capitanio, M. (2022). High-Speed Optical Traps Address Dynamics of Processive and Non-Processive Molecular Motors. Methods in Molecular Biology (Clifton, N.J.), 2478, 513–557. https://doi.org/10.1007/978-1-0716-2229-2_19

Gardini, L., Woody, M. S., Kashchuk, A. v., Goldman, Y. E., Ostap, E. M., & Capitanio, M. (2022). High-Speed Optical Traps Address Dynamics of Processive and Non-Processive Molecular Motors. Methods in Molecular Biology (Clifton, N.J.), 2478, 513–557. https://doi.org/10.1007/978-1-0716-2229-2_19

Heo, S.-J., Thakur, S., Chen, X., Loebel, C., Xia, B., McBeath, R., Burdick, J. A., Shenoy, V. B., Mauck, R. L., & Lakadamyali, M. (2022). Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues. Nature Biomedical Engineering 2022, 1–15. https://doi.org/10.1038/s41551-022-00910-5

Heo, S.-J., Thakur, S., Chen, X., Loebel, C., Xia, B., McBeath, R., Burdick, J. A., Shenoy, V. B., Mauck, R. L., & Lakadamyali, M. (2022). Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues. Nature Biomedical Engineering 2022, 1–15. https://doi.org/10.1038/s41551-022-00910-5
**  NOTE:  see press release for this publication HERE.

Jing, H., Korasick, D. A., Emenecker, R. J., Morffy, N., Wilkinson, E. G., Powers, S. K., & Strader, L. C. (2022). Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning. Nature Communications, 13(4015). https://doi.org/10.1038/s41467-022-31628-2

Jing, H., Korasick, D. A., Emenecker, R. J., Morffy, N., Wilkinson, E. G., Powers, S. K., & Strader, L. C. (2022). Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning. Nature Communications, 13(4015). https://doi.org/10.1038/s41467-022-31628-2

Kegelman, C. D., Collins, J. M., Nijsure, M. P., Eastburn, E. A., & Boerckel, J. D. (2020). Gone caving: Roles of the transcriptional regulators yap and taz in skeletal development. In Current Osteoporosis Reports (Vol. 18, Issue 5, pp. 526–540). Springer. https://doi.org/10.1007/s11914-020-00605-3

Kegelman, C. D., Collins, J. M., Nijsure, M. P., Eastburn, E. A., & Boerckel, J. D. (2020). Gone caving: Roles of the transcriptional regulators yap and taz in skeletal development. In Current Osteoporosis Reports (Vol. 18, Issue 5, pp. 526–540). Springer. https://doi.org/10.1007/s11914-020-00605-3

Linares-Saldana, R., Kim, W., Bolar, N. A., Zhang, H., Koch-Bojalad, B. A., Yoon, S., Shah, P. P., Karnay, A., Park, D. S., Luppino, J. M., Nguyen, S. C., Padmanabhan, A., Smith, C. L., Poleshko, A., Wang, Q., Li, L., Srivastava, D., Vahedi, G., Eom, G. H., Blobel, G. A., Joyce, E. F., and Jain, R. (2021). BRD4 orchestrates genome folding to promote neural crest differentiation. Nature Genetics, 53(10), 1480–1492. https://doi.org/10.1038/s41588-021-00934-8

Linares-Saldana, R., Kim, W., Bolar, N. A., Zhang, H., Koch-Bojalad, B. A., Yoon, S., Shah, P. P., Karnay, A., Park, D. S., Luppino, J. M., Nguyen, S. C., Padmanabhan, A., Smith, C. L., Poleshko, A., Wang, Q., Li, L., Srivastava, D., Vahedi, G., Eom, G. H., Blobel, G. A., Joyce, E. F., and Jain, R. (2021). BRD4 orchestrates genome folding to promote neural crest differentiation. Nature Genetics, 53(10), 1480–1492. https://doi.org/10.1038/s41588-021-00934-8

Liu, S., Yang, H., Lu, T. J., Genin, G. M., & Xu, F. (2019). Electrostatic switching of nuclear basket conformations provides a potential mechanism for nuclear mechanotransduction. Journal of the Mechanics and Physics of Solids, 133, 103705. https://doi.org/10.1016/j.jmps.2019.103705

Liu, S., Yang, H., Lu, T. J., Genin, G. M., & Xu, F. (2019). Electrostatic switching of nuclear basket conformations provides a potential mechanism for nuclear mechanotransduction. Journal of the Mechanics and Physics of Solids, 133, 103705. https://doi.org/10.1016/j.jmps.2019.103705

Łysik, D., Deptuła, P., Chmielewska, S., Skłodowski, K., Pogoda, K., Chin, L., Song, D., Mystkowska, J., Janmey, P. A., & Bucki, R. (2022). Modulation of Biofilm Mechanics by DNA Structure and Cell Type. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/ACSBIOMATERIALS.2C00777

Łysik, D., Deptuła, P., Chmielewska, S., Skłodowski, K., Pogoda, K., Chin, L., Song, D., Mystkowska, J., Janmey, P. A., & Bucki, R. (2022). Modulation of Biofilm Mechanics by DNA Structure and Cell Type. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/ACSBIOMATERIALS.2C00777

Mason, D. E., Collins, J. M., Dawahare, J. H., Nguyen, T. D., Lin, Y., Voytik-Harbin, S. L., Zorlutuna, P., Yoder, M. C., & Boerckel, J. D. (2019). YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility. Journal of Cell Biology, 218(4), 1369–1389. https://doi.org/10.1083/jcb.201806065

Mason, D. E., Collins, J. M., Dawahare, J. H., Nguyen, T. D., Lin, Y., Voytik-Harbin, S. L., Zorlutuna, P., Yoder, M. C., & Boerckel, J. D. (2019). YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility. Journal of Cell Biology, 218(4), 1369–1389. https://doi.org/10.1083/jcb.201806065

Mellis, I. A., Edelstein, H. I., Truitt, R., Goyal, Y., Beck, L. E., Symmons, O., Dunagin, M. C., Linares Saldana, R. A., Shah, P. P., Pérez-Bermejo, J. A., Padmanabhan, A., Yang, W., Jain, R., & Raj, A. (2021). Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Systems. https://doi.org/10.1016/J.CELS.2021.07.003

Mellis, I. A., Edelstein, H. I., Truitt, R., Goyal, Y., Beck, L. E., Symmons, O., Dunagin, M. C., Linares Saldana, R. A., Shah, P. P., Pérez-Bermejo, J. A., Padmanabhan, A., Yang, W., Jain, R., & Raj, A. (2021). Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Systems. https://doi.org/10.1016/J.CELS.2021.07.003

Neguembor, M. V., Martin, L., Castells-García, Á., Gómez-García, P. A., Vicario, C., Carnevali, D., AlHaj Abed, J., Granados, A., Sebastian-Perez, R., Sottile, F., Solon, J., Wu, C., Lakadamyali, M., & Cosma, M. P. (2021). Transcription-mediated supercoiling regulates genome folding and loop formation. Molecular Cell, 81(15), 3065-3081.e12. https://doi.org/10.1016/J.MOLCEL.2021.06.009

Neguembor, M. V., Martin, L., Castells-García, Á., Gómez-García, P. A., Vicario, C., Carnevali, D., AlHaj Abed, J., Granados, A., Sebastian-Perez, R., Sottile, F., Solon, J., Wu, C., Lakadamyali, M., & Cosma, M. P. (2021). Transcription-mediated supercoiling regulates genome folding and loop formation. Molecular Cell, 81(15), 3065-3081.e12. https://doi.org/10.1016/J.MOLCEL.2021.06.009

Pfeifer, C. R., Tobin, M. P., Cho, S., Vashisth, M., Dooling, L. J., Vazquez, L. L., Ricci-De Lucca, E. G., Simon, K. T., & Discher, D. E. (2022). Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus, 13(1), 129–143. https://www.tandfonline.com/doi/full/10.1080/19491034.2022.2045726

Pfeifer, C. R., Tobin, M. P., Cho, S., Vashisth, M., Dooling, L. J., Vazquez, L. L., Ricci-De Lucca, E. G., Simon, K. T., & Discher, D. E. (2022). Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus, 13(1), 129–143.  https://www.tandfonline.com/doi/full/10.1080/19491034.2022.2045726

Pfeifer, C. R., Tobin, M. P., Cho, S., Vashisth, M., Dooling, L. J., Vazquez, L. L., Ricci-De Lucca, E. G., Simon, K. T., & Discher, D. E. (2022). Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus, 13(1), 129–143. https://doi.org/10.1080/19491034.2022.2045726

Pfeifer, C. R., Tobin, M. P., Cho, S., Vashisth, M., Dooling, L. J., Vazquez, L. L., Ricci-De Lucca, E. G., Simon, K. T., & Discher, D. E. (2022). Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus, 13(1), 129–143. https://doi.org/10.1080/19491034.2022.2045726

Poleshko, A., Shah, P. P., Gupta, M., Babu, A., Morley, M. P., Manderfield, L. J., Ifkovits, J. L., Calderon, D., Aghajanian, H., Sierra-Pagán, J. E., Sun, Z., Wang, Q., Li, L., Dubois, N. C., Morrisey, E. E., Lazar, M. A., Smith, C. L., Epstein, J. A., & Jain, R. (2017). Genome-nuclear lamina interactions regulate cardiac stem cell lineage restriction. Cell, 171(3), 573-587.e14. https://doi.org/10.1016/j.cell.2017.09.018

Poleshko, A., Shah, P. P., Gupta, M., Babu, A., Morley, M. P., Manderfield, L. J., Ifkovits, J. L., Calderon, D., Aghajanian, H., Sierra-Pagán, J. E., Sun, Z., Wang, Q., Li, L., Dubois, N. C., Morrisey, E. E., Lazar, M. A., Smith, C. L., Epstein, J. A., & Jain, R. (2017). Genome-nuclear lamina interactions regulate cardiac stem cell lineage restriction. Cell, 171(3), 573-587.e14. https://doi.org/10.1016/j.cell.2017.09.018

Poleshko, A., Smith, C. L., Nguyen, S. C., Sivaramakrishnan, P., Wong, K. G., Murray, J. I., Lakadamyali, M., Joyce, E. F., Jain, R., & Epstein, J. A. (2019). H3k9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. ELife, 8. https://doi.org/10.7554/eLife.49278

Poleshko, A., Smith, C. L., Nguyen, S. C., Sivaramakrishnan, P., Wong, K. G., Murray, J. I., Lakadamyali, M., Joyce, E. F., Jain, R., & Epstein, J. A. (2019). H3k9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. ELife, 8. https://doi.org/10.7554/eLife.49278

Price, C. C., Mathur, J., Boerckel, J. D., Pathak, A., & Shenoy, V. B. (2021). Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory. Biophysical Journal, 120(22), 5074–5089. https://doi.org/10.1016/J.BPJ.2021.10.006

Price, C. C., Mathur, J., Boerckel, J. D., Pathak, A., & Shenoy, V. B. (2021). Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory. Biophysical Journal, 120(22), 5074–5089. https://doi.org/10.1016/J.BPJ.2021.10.006

See, K., Kiseleva, A. A., Smith, C. L., Liu, F., Li, J., Poleshko, A., & Epstein, J. A. (2020). Histone methyltransferase activity programs nuclear peripheral genome positioning. Developmental Biology, 466(1–2), 90–98. https://doi.org/10.1016/j.ydbio.2020.07.010

See, K., Kiseleva, A. A., Smith, C. L., Liu, F., Li, J., Poleshko, A., & Epstein, J. A. (2020). Histone methyltransferase activity programs nuclear peripheral genome positioning. Developmental Biology, 466(1–2), 90–98. https://doi.org/10.1016/j.ydbio.2020.07.010

Seo, J., Byun, W. Y., Alisafaei, F., Georgescu, A., Yi, Y. S., Massaro-Giordano, M., Shenoy, V. B., Lee, V., Bunya, V. Y., & Huh, D. (2019). Multiscale reverse engineering of the human ocular surface. Nature Medicine, 25(8), 1310–1318. https://doi.org/10.1038/s41591-019-0531-2

Seo, J., Byun, W. Y., Alisafaei, F., Georgescu, A., Yi, Y. S., Massaro-Giordano, M., Shenoy, V. B., Lee, V., Bunya, V. Y., & Huh, D. (2019). Multiscale reverse engineering of the human ocular surface. Nature Medicine, 25(8), 1310–1318. https://doi.org/10.1038/s41591-019-0531-2

Shah, P. P., Lv, W., Rhoades, J. H., Poleshko, A., Abbey, D., Caporizzo, M. A., Linares-Saldana, R., Heffler, J. G., Sayed, N., Thomas, D., Wang, Q., Stanton, L. J., Bedi, K., Morley, M. P., Cappola, T. P., Owens, A. T., Margulies, K. B., Frank, D. B., Wu, J. C., Rader, D.J., Yang, W., Prosser, B.L., Musunuru, K., Jain, R. (2021). Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell, 28, 1–17. https://doi.org/10.1016/j.stem.2020.12.016

Shah, P. P., Lv, W., Rhoades, J. H., Poleshko, A., Abbey, D., Caporizzo, M. A., Linares-Saldana, R., Heffler, J. G., Sayed, N., Thomas, D., Wang, Q., Stanton, L. J., Bedi, K., Morley, M. P., Cappola, T. P., Owens, A. T., Margulies, K. B., Frank, D. B., Wu, J. C., Rader, D.J., Yang, W., Prosser, B.L., Musunuru, K., Jain, R. (2021). Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell, 28, 1–17.     https://doi.org/10.1016/j.stem.2020.12.016

**  NOTE:  new video for this publication HERE.

Vashisth, M., Cho, S., Irianto, J., Xia, Y., Wang, M., Hayes, B., Wieland, D., Wells, R., Jafarpour, F., Liu, A., & Discher, D. E. (2021). Scaling concepts in ’omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 118(48). https://doi.org/10.1073/PNAS.2112940118/-/DCSUPPLEMENTAL

Vashisth, M., Cho, S., Irianto, J., Xia, Y., Wang, M., Hayes, B., Wieland, D., Wells, R., Jafarpour, F., Liu, A., & Discher, D. E. (2021). Scaling concepts in ’omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 118(48). https://doi.org/10.1073/PNAS.2112940118

Xia, Y., Cho, S., Vashisth, M., Ivanovska, I. L., Dingal, P. C. D. P., & Discher, D. E. (2019). Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods, 157, 3–14. https://doi.org/10.1016/j.ymeth.2018.12.009

Xia, Y., Cho, S., Vashisth, M., Ivanovska, I. L., Dingal, P. C. D. P., & Discher, D. E. (2019). Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods, 157, 3–14. https://doi.org/10.1016/j.ymeth.2018.12.009

Xia, Y., Ivanovska, I. L., Zhu, K., Smith, L., Irianto, J., Pfeifer, C. R., Alvey, C. M., Ji, J., Liu, D., Cho, S., Bennett, R. R., Liu, A. J., Greenberg, R. A., & Discher, D. E. (2018). Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, 217(11), 3796–3808. https://doi.org/10.1083/jcb.201711161

Xia, Y., Ivanovska, I. L., Zhu, K., Smith, L., Irianto, J., Pfeifer, C. R., Alvey, C. M., Ji, J., Liu, D., Cho, S., Bennett, R. R., Liu, A. J., Greenberg, R. A., & Discher, D. E. (2018). Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. Journal of Cell Biology, 217(11), 3796–3808. https://doi.org/10.1083/jcb.201711161

Xia, Y., Pfeifer, C. R., Zhu, K., Irianto, J., Liu, D., Pannell, K., Chen, E. J., Dooling, L. J., Tobin, M. P., Wang, M., Ivanovska, I. L., Smith, L. R., Greenberg, R. A., & Discher, D. E. (2019). Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of Cell Biology, 218(8), 2545–2563. https://doi.org/10.1083/jcb.201811100

Xia, Y., Pfeifer, C. R., Zhu, K., Irianto, J., Liu, D., Pannell, K., Chen, E. J., Dooling, L. J., Tobin, M. P., Wang, M., Ivanovska, I. L., Smith, L. R., Greenberg, R. A., & Discher, D. E. (2019). Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of Cell Biology, 218(8), 2545–2563. https://doi.org/10.1083/jcb.201811100

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