Elizabeth Haswell, PhD and professor of biology at Washington University in St. Louis and postdoctoral research scholar, Dabarati Basu have discovered the mechanosensitive ion channels in the plant’s cells that respond to swelling by inducing cell death — potentially to protect the rest of the plant. The discovery — reported by Haswell and Debarati Basu, […]
In a recent paper published in Hepatology, CEMB’s Rebecca G. Wells, reports on creating the first bile duct-on-a-chip, making it possible for more-complete research to be conducted without the need for human or animal participants. “Bile ducts pose great challenges to researchers because of their location and their complex function and cellular structure, which has […]
Plant biologist Lucia Strader in the School of Arts & Sciences at Washington University in St. Louis discovered a cellular transporter that regulates root initiation and progression. Roots anchor plants in place and allow them to absorb nutrient from soil. But the process of growing new roots is costly to a plant, and there can […]
Ben Prosser, Assistant Professor of Physiology and CEMB faculty researcher and his colleague, Ken Margulies recently reported in Nature Medicine, promising work into restoring elasticity to previously ‘damaged’ and stiff cardiac muscle cells. The work focuses on the microtubules within a single cardiac cell. Diseased cells fill up with greater numbers of these filaments increasing ...
A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and the space between muscles, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, Mount Sinai Beth Israel Medical Center, and the New York University School of […]
Congrats to CEMB PIs Vivek Shenoy, Jason Burdick, Paul Janmey, and Robert Mauck and their new publication on how matching material and cellular timescales effects cell spreading in viscoelastic substrates. Read more in the Proceedings of the National Academy of Sciences.
Two new publications from the lab of Ram Dixit at Washington University in St. Louis indicate how kinesin motor proteins and the microtubule tracks on which they move are regulated in plant cells. Kinesins are proteins that work as “engines” that carry material from one part of the cell to the next. As a transporter […]
Mechanics of Muscle Cells Revealed: Ostap and Sindelar Use Advanced Microscopy to Show Myosin’s Role in Contraction
The Winter Olympics are dominating news headlines, but how do speed skaters and downhill skiers summon the speed to go for the gold? Muscles – contracting slow and fast – allow these athletes to power through the race and sprint to the finish. The remarkable nanometer-sized cellular machines that drive muscle contraction are called myosins. […]
Science by CEMB member Treena Livingston Arinzeh of New Jersey Institute of Technology appears in Sigma Xi’s magazine American Scientist, Sept/Oct 2017 edition. Arinzeh’s work with colleagues Moy and Huang examines how engineered scaffold structures shed light on cell growth, and thus can help “find new ways to regenerate bone, cartilage, and nerve tissue and […]