Paul Janmey, Ph.D., is Professor of Physiology at the University of Pennsylvania. He also holds graduate group affiliations in Cell and Molecular Biology and Biochemistry and Molecular Biophysics. He is a Co-Leader of Working Group 2 for the CEMB.
The Janmey lab studies how forces applied to the cell or the stiffness of the extracellular matrix affects cell structure and function. Janmey and his group produce soft biocompatible materials to study how matrix stiffness alters cell structure, differentiation, and growth. In related work, Paul’s lab measures the structure and mechanics of cytoskeletal and extracellular matrix polymers using imaging, scattering, and rheologic methods, and examines how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.
Keywords: cytoskeleton; phosphoinositide signaling; cell mechanics; actin; PIP2; gel; astrocyte; fibrin; gelsolin; cellular engineering; bioengineered therapeutics; devices and drug delivery; cardiovascular and pulmonary cell and tissue mechanics; mechanobiology
Working Group(s): Working Group 2: How do cells adapt to and change their mechanical environment?