Joel Boerckel, PhD

2018 SEED Grant Recipient

2018 SEED project summary:  Cells are able to respond to a variety of mechanical stimuli, from fluid shear blood vessel cells, to the changing mechanical properties of the environment in which a cancer cell resides. Cells interpret these mechanical stimuli through a process called “mechanosensation” and translate them into the biochemical language of the cell through “mechanotransduction.” It is often assumed that the progression of mechanosensation to mechanotransduction is a one-way-street, but there is evidence that the biochemical products of mechanotransduction can also regulate how the cells performs mechanosensation. The goal of this project is to understand how these mechanotransductive feedback loops work.

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