Seminars and Symposia

Workshop:

Magnetorheological Soft Materials for Mechanobiology

  • Monday, June 10, 2019 – Reading Room @3231 Walnut Street (LRSM)

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Keynote Lecture:

Magnetostriction of Ferrogels

Andrejs Cēbers, Professor, Laboratory of Soft Magnetic Matter University of Latvia,

Incorporation of ferromagnetic particles in a soft material enables large and rapid changes to their elastic moduli when a magnetic field is applied. Material constants responsible for the magnetostriction of magnetic gels are derived by using a local effective field approach. As an example, the classical problem of deformation of an ellipsoidal sample of ferrogel is considered by using the virial method. The relations obtained for material constants are applied to experimental data for the shear modulus of a ferrogel and the normal force acting on the plates of a rheometer as a function of the applied field. The theory predicts a quadratic dependence of shear storage modulus and normal force on the field strength, in agreement with experimental data. This analysis also provides estimates of magnetic permeability of the ferrogel, which are in reasonable agreement with experiments.

This workshop is FREE.  Registration is required.

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Paris-Philadelphia Mechanobiology Symposium

  • Thursday, December 13, 2018 – ALC @ 3401 Walnut Street (4th floor)
  • Friday, December 14, 2018 – Reading Room @3231 Walnut Street (LRSM)
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This symposium is FREE.  Registration is Closed.

Contact jmcgon@seas.upenn.edu regarding Waitlist

Breakfast and lunch are included.
Download Agenda (PDF)

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Distinguished Lecture

Alexander D. Bershadsky, Ph.D.

Mechanobiology Institute, National University of Singapore and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Cytoskeletal self-organization and cell morphogenesis

Monday, May 21, 2018
Singh Center for Nanotechnology
4:00 PM (a reception will follow)

Abstract

Actomyosin cytoskeleton, microtubules, and cell-matrix adhesions are the key elements determining cell morphogenesis. Peripheral domains of the actomyosin cytoskeleton associated with the clusters of integrin transmembrane receptors comprise several types of cell-matrix adhesions, such as focal adhesions and podosomes. Myosin-IIA-filaments assemble into superstructures (“stacks”) organizing and remodeling the actin filament networks, including cell-matrix adhesions. A feedback response from the integrin adhesions to the myosin IIA filaments is in part mediated by another essential cytoskeletal system, microtubules. The myosin-IIA filament assembly depends on Rho activation by guanine nucleotide exchange factor GEF-H1, which is trapped by microtubules when they are connected with integrin adhesions via KANK family proteins but released after their disconnection.  Finally, the emergence of left-right asymmetry in the course of actomyosin cytoskeleton self-organization depends on formin-driven actin polymerization.