Paris-Philadelphia Mechanobiology Symposium
- Thursday, December 13, 2018 – ALC @ 3401 Walnut Street (4th floor)
- Friday, December 14, 2018 – Reading Room @3231 Walnut Street (LRSM)
This symposium is FREE. Registration is Closed.
Contact firstname.lastname@example.org regarding Waitlist
Breakfast and lunch are included.
**** PAST EVENTS ****
Alexander D. Bershadsky, Ph.D.
Mechanobiology Institute, National University of Singapore and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Cytoskeletal self-organization and cell morphogenesis
Monday, May 21, 2018
Singh Center for Nanotechnology
4:00 PM (a reception will follow)
Actomyosin cytoskeleton, microtubules, and cell-matrix adhesions are the key elements determining cell morphogenesis. Peripheral domains of the actomyosin cytoskeleton associated with the clusters of integrin transmembrane receptors comprise several types of cell-matrix adhesions, such as focal adhesions and podosomes. Myosin-IIA-filaments assemble into superstructures (“stacks”) organizing and remodeling the actin filament networks, including cell-matrix adhesions. A feedback response from the integrin adhesions to the myosin IIA filaments is in part mediated by another essential cytoskeletal system, microtubules. The myosin-IIA filament assembly depends on Rho activation by guanine nucleotide exchange factor GEF-H1, which is trapped by microtubules when they are connected with integrin adhesions via KANK family proteins but released after their disconnection. Finally, the emergence of left-right asymmetry in the course of actomyosin cytoskeleton self-organization depends on formin-driven actin polymerization.