Seminars and Symposia

Paris-Philadelphia Mechanobiology Symposium

  • Thursday, December 13, 2018 – ALC @ 3401 Walnut Street (4th floor)
  • Friday, December 14, 2018 – Reading Room @3231 Walnut Street (LRSM)
Download Agenda (PDF)

        

This symposium is FREE.  Registration is Closed.

Contact jmcgon@seas.upenn.edu regarding Waitlist

Breakfast and lunch are included.
Download Agenda (PDF)

****  PAST EVENTS  ****

Distinguished Lecture

Alexander D. Bershadsky, Ph.D.

Mechanobiology Institute, National University of Singapore and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Cytoskeletal self-organization and cell morphogenesis

Monday, May 21, 2018
Singh Center for Nanotechnology
4:00 PM (a reception will follow)

Abstract

Actomyosin cytoskeleton, microtubules, and cell-matrix adhesions are the key elements determining cell morphogenesis. Peripheral domains of the actomyosin cytoskeleton associated with the clusters of integrin transmembrane receptors comprise several types of cell-matrix adhesions, such as focal adhesions and podosomes. Myosin-IIA-filaments assemble into superstructures (“stacks”) organizing and remodeling the actin filament networks, including cell-matrix adhesions. A feedback response from the integrin adhesions to the myosin IIA filaments is in part mediated by another essential cytoskeletal system, microtubules. The myosin-IIA filament assembly depends on Rho activation by guanine nucleotide exchange factor GEF-H1, which is trapped by microtubules when they are connected with integrin adhesions via KANK family proteins but released after their disconnection.  Finally, the emergence of left-right asymmetry in the course of actomyosin cytoskeleton self-organization depends on formin-driven actin polymerization.