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February 21, 2025 1:30-3pm ET | 12:30pm CT | 10:30am PT
Zoom Link: https://upenn.zoom.us/
Speaker: Prof. Dr. Ingolf Sack, Berlin School of Integrative Oncology
Title: On the relationship between viscoelasticity and water diffusion in soft biological tissues
Abstract
The biophysical properties of biological soft tissues are controlled by cellular and extracellular matrix (ECM) components and the biophysical signals they exchange. Although these interactions occur at the microscopic level, they can influence water diffusion and mechanical tissue properties at the macroscopic level, as resolved by medical imaging modalities and used for clinical diagnosis. In particular, diffusion-weighted imaging (DWI) and magnetic resonance elastography (MRE) provide complementary contrasts of tissue stiffness, fluidity, viscosity, and water mobility. After introducing the physical concepts of DWI and MRE, this talk will address the wide range of correlations between biophysical imaging signals in systems relevant to soft biological tissues and discuss complex parameter changes based on the two fundamental tissue properties, polarity and solid fraction.
