Title: Getting a hold on chromatin: Understanding nuclear processes through micromanipulation
Speaker: Veer Keizer, PhD
Larson Group, National Cancer Institute (NIH)
Date: September 18, 11a-12p ET | 10 am CT | 8am PT
Zoom Link:
https://upenn.zoom.us/j/
Have you ever wondered what chromatin is like in the nucleus of a living cell? In this talk, Veer Keizer will discuss a novel tool to actively manipulate chromatin in live cells using magnetism. By physically moving chromatin through the nuclear space, Her team gained a better understanding of key chromatin characteristics and chromatin organization. The observed behavior could be recapitulated with a Rouse model that includes only a weak obstructive effect of the surrounding chromatin and nucleoplastic material. This challenges the view that interphase chromatin is a gel-like material and has important implications for nuclear functions such as transcription and DNA damage repair.
