Special Seminar: Allen Ehrlicher, PhD
Associate Professor, Canada Research Chair in Active Biological Mechanics, McGill University
Title: “Nuclear mechanosensing and cancer metastasis biophysics”
Abstract: Cancers are associated with a myriad of diverse biochemical changes; however, many cancers are observed to display similar changes in the mechanics and active contractile properties, including softening and increased contractility. These changes are consistent with biophysics that facilitates cell migration, promoting an invasive metastatic phenotype. Nevertheless, these mechanical challenges may also influence cell behavior through biochemical mechanotransduction. In particular, we suspect that nuclear deformation mechanosensing may be a key regulatory mechanism in cancer pathology and developmental physiology. In this talk, I’ll describe some of our group’s ongoing work in quantifying the contractile and mechanical changes in cancer and dissecting the relationship between cell mechanics and nuclear mechanosensing.
The Friday Seminar Series is CEMB’s biweekly meeting of all members across the Center. Recurring themes center on the Integrated Research Thrusts (IRTs) of 1) the Cell-Matrix Dialogue; 2) the Nucleus and Mechanical Memory; and 3) Tissue Mechanics in 4D. If you wish to attend, please REGISTER HERE to obtain the Zoom meeting link. CEMB members receive regular announcements of these meetings through our mailing list and newsletter.
The dates for this fall are:
December 3rd and 17th