Research

Healing interventions for spinal disc injuries

By James McGonigle on November 18, 2019

Researchers in the Mauck group have discovered that using a biological inhibitor to prevent cells in the spinal cord from becoming stressed and starting a subpar healing process gives doctors more time to treat injuries before they worsen. “These data show us that treating disc injuries very soon after injury is essential before this transition in […]

Why Tissue Gets Stiffer When Compressed

By Annie Jeong on October 16, 2019

In a study recently published in Nature, Drs. Paul Janmey and Vivek Shenoy, along with their graduate students Anne van Oosten and Xingyu Chen and collaborators, have answered the long-standing biomedical paradox of why tissues stiffen when compressed.  Reported in The Medium, the researchers found that when tissue is compressed, the cells inside expand laterally, […]

[img] Rebecca Wells

Organ-Level Function on a Chip: Bile Duct-on-a-Chip

By James McGonigle on October 8, 2019

In a recent paper published in Hepatology, CEMB’s Rebecca G. Wells, reports on creating the first bile duct-on-a-chip, making it possible for more-complete research to be conducted without the need for human or animal participants. “Bile ducts pose great challenges to researchers because of their location and their complex function and cellular structure, which has […]

[img] Lucia Strader

Plant Cell Mechanobiology Blossoming at WashU

By James McGonigle on August 14, 2019

Plant biologist Lucia Strader in the School of Arts & Sciences at Washington University in St. Louis discovered a cellular transporter that regulates root initiation and progression.  Roots anchor plants in place and allow them to absorb nutrient from soil.  But the process of growing new roots is costly to a plant, and there can […]

Organs-on-Chips and Organoids: Best of Both Worlds

By James McGonigle on June 11, 2019

Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the  lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung.  ...

Replicating fetal bone growth process could help heal large bone defects

By James McGonigle on June 10, 2019

From Penn Today:  June 6, 2019:  To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]

Cells Control Their Own Fate by Manipulating their Environment

By James McGonigle on April 11, 2019

As stem cells differentiate into functional specialized cells, the process is controlled through signals from their surroundings.  In a recent paper published in Nature Materials, this CEMB study suggests that cells may have more control over their fate than previously thought. The study found that cells secrete proteins within hours of being encapsulated in specialized […]

[img] Dan Huh

Dan Huh Wins 2018 Lush Science Prize for Organ-on-a-Chip Work

By James McGonigle on February 11, 2019

The Lush Prize is a major initiative aiming to bring forward the day when safety testing takes place without the use of animals.  It focuses pressure on toxicity testing for consumer products and ingredients, in a way which complements the many projects already addressing the use of animals in medical testing.  The Lush Prize rewards […]

[img] Rebecca Wells

“Interstitium” may be shock absorber to many organs and tissues

By James McGonigle on April 11, 2018

A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and the space between muscles, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, Mount Sinai Beth Israel Medical Center, and the New York University School of […]