“Engineered lung alveolar organoids to probe fibrotic remodeling in COVID-19 induced lung injuries” Claudia Loebel, MD/PhD and Matthew Davidson, PhD (PI: Jason Burdick) Abstract: Using engineered alveolar organoids and secreted extracellular matrix (ECM) labeling and stiffening techniques, we will monitor cell behavior in response to mechanical perturbations and antiviral treatment. Specif...
Researchers in the Mauck group have discovered that using a biological inhibitor to prevent cells in the spinal cord from becoming stressed and starting a subpar healing process gives doctors more time to treat injuries before they worsen. “These data show us that treating disc injuries very soon after injury is essential before this transition in […]
In a study recently published in Nature, Drs. Paul Janmey and Vivek Shenoy, along with their graduate students Anne van Oosten and Xingyu Chen and collaborators, have answered the long-standing biomedical paradox of why tissues stiffen when compressed. Reported in The Medium, the researchers found that when tissue is compressed, the cells inside expand laterally, […]
In a recent paper published in Hepatology, CEMB’s Rebecca G. Wells, reports on creating the first bile duct-on-a-chip, making it possible for more-complete research to be conducted without the need for human or animal participants. “Bile ducts pose great challenges to researchers because of their location and their complex function and cellular structure, which has […]
Plant biologist Lucia Strader in the School of Arts & Sciences at Washington University in St. Louis discovered a cellular transporter that regulates root initiation and progression. Roots anchor plants in place and allow them to absorb nutrient from soil. But the process of growing new roots is costly to a plant, and there can […]
Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung. ...
From Penn Today: June 6, 2019: To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]
As stem cells differentiate into functional specialized cells, the process is controlled through signals from their surroundings. In a recent paper published in Nature Materials, this CEMB study suggests that cells may have more control over their fate than previously thought. The study found that cells secrete proteins within hours of being encapsulated in specialized […]
The Lush Prize is a major initiative aiming to bring forward the day when safety testing takes place without the use of animals. It focuses pressure on toxicity testing for consumer products and ingredients, in a way which complements the many projects already addressing the use of animals in medical testing. The Lush Prize rewards […]
(News item prepared by Patience Graybill, Wash U) Researchers have thought that cancer begins when a single cell goes rogue in the body then begins to grow and multiply. Now, they are investigating evidence of more damage when a group of cells breaks off from a colony and more follow, leading to large-scale metastasis. Amit […]