Research

[img] Haswell

When it Rains……. It Swells.

By James McGonigle on June 24, 2020

Elizabeth Haswell, PhD and professor of biology at Washington University in St. Louis and postdoctoral research scholar, Dabarati Basu have discovered the mechanosensitive ion channels in the plant’s cells that respond to swelling by inducing cell death — potentially to protect the rest of the plant. The discovery — reported by Haswell and Debarati Basu, […]

[img] Benjamin Prosser

Ben Prosser to Co-Lead $6.5 Million Transatlantic Grant to Investigate Cytoskeleton’s Role in Heart Disease

By James McGonigle on June 22, 2020

Benjamin L. Prosser, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania, will serve as the North American coordinator for a new, multi-institutional $6.5 million grant from the Leducq Foundation, aimed at better understanding the role the heart cell cytoskeleton plays in heart disease and finding new ways to […]

[img] Dixit

Motor proteins create more stable tracks to deliver much-needed materials in plant cells

By James McGonigle on June 12, 2020

From WashU’s, The Source. June 2, 2020. As a plant grows, it moves cellular material from its version of manufacturing sites to the cell wall construction zone. Transporter proteins, called motor proteins, are thought to move these cell wall cargo via a complex highway system made up of microtubule tracks. The position of these tracks […]

New COVID-19 Research Project from CEMB Postdoctoral Research Trainees

By James McGonigle on April 26, 2020

“Engineered lung alveolar organoids to probe fibrotic remodeling in COVID-19 induced lung injuries” Claudia Loebel, MD/PhD and Matthew Davidson, PhD (PI: Jason Burdick)   Abstract:  Using engineered alveolar organoids and secreted extracellular matrix (ECM) labeling  and stiffening techniques, we will monitor cell behavior in response to mechanical perturbations and antiviral treatment.  Specif...

Healing interventions for spinal disc injuries

By James McGonigle on November 18, 2019

Researchers in the Mauck group have discovered that using a biological inhibitor to prevent cells in the spinal cord from becoming stressed and starting a subpar healing process gives doctors more time to treat injuries before they worsen. “These data show us that treating disc injuries very soon after injury is essential before this transition in […]

Why Tissue Gets Stiffer When Compressed

By Annie Jeong on October 16, 2019

In a study recently published in Nature, Drs. Paul Janmey and Vivek Shenoy, along with their graduate students Anne van Oosten and Xingyu Chen and collaborators, have answered the long-standing biomedical paradox of why tissues stiffen when compressed.  Reported in The Medium, the researchers found that when tissue is compressed, the cells inside expand laterally, […]

[img] Rebecca Wells

Organ-Level Function on a Chip: Bile Duct-on-a-Chip

By James McGonigle on October 8, 2019

In a recent paper published in Hepatology, CEMB’s Rebecca G. Wells, reports on creating the first bile duct-on-a-chip, making it possible for more-complete research to be conducted without the need for human or animal participants. “Bile ducts pose great challenges to researchers because of their location and their complex function and cellular structure, which has […]

[img] Lucia Strader

Plant Cell Mechanobiology Blossoming at WashU

By James McGonigle on August 14, 2019

Plant biologist Lucia Strader in the School of Arts & Sciences at Washington University in St. Louis discovered a cellular transporter that regulates root initiation and progression.  Roots anchor plants in place and allow them to absorb nutrient from soil.  But the process of growing new roots is costly to a plant, and there can […]

Organs-on-Chips and Organoids: Best of Both Worlds

By James McGonigle on June 11, 2019

Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the  lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung.  ...

Replicating fetal bone growth process could help heal large bone defects

By James McGonigle on June 10, 2019

From Penn Today:  June 6, 2019:  To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]