Research

Organs-on-Chips and Organoids: Best of Both Worlds

By James McGonigle on June 11, 2019

Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the  lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung.  ...

Replicating fetal bone growth process could help heal large bone defects

By James McGonigle on June 10, 2019

From Penn Today:  June 6, 2019:  To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]

Cells Control Their Own Fate by Manipulating their Environment

By James McGonigle on April 11, 2019

As stem cells differentiate into functional specialized cells, the process is controlled through signals from their surroundings.  In a recent paper published in Nature Materials, this CEMB study suggests that cells may have more control over their fate than previously thought. The study found that cells secrete proteins within hours of being encapsulated in specialized […]

[img] Dan Huh

Dan Huh Wins 2018 Lush Science Prize for Organ-on-a-Chip Work

By James McGonigle on February 11, 2019

The Lush Prize is a major initiative aiming to bring forward the day when safety testing takes place without the use of animals.  It focuses pressure on toxicity testing for consumer products and ingredients, in a way which complements the many projects already addressing the use of animals in medical testing.  The Lush Prize rewards […]

[img] Rebecca Wells

“Interstitium” may be shock absorber to many organs and tissues

By James McGonigle on April 11, 2018

A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and the space between muscles, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, Mount Sinai Beth Israel Medical Center, and the New York University School of […]

myosin video link

Mechanics of Muscle Cells Revealed: Ostap and Sindelar Use Advanced Microscopy to Show Myosin’s Role in Contraction

By Patience on February 27, 2018

The Winter Olympics are dominating news headlines, but how do speed skaters and downhill skiers summon the speed to go for the gold? Muscles – contracting slow and fast – allow these athletes to power through the race and sprint to the finish. The remarkable nanometer-sized cellular machines that drive muscle contraction are called myosins. […]

Jason Burdick

Jason Burdick receives Heilmeier Research Award

By Patience on February 1, 2018

Jason Burdick, Professor in Bioengineering, has been named the recipient of the 2017-18 George H. Heilmeier Faculty Award for Excellence in Research for “pioneering contributions to designing and developing polymers for applications in stem cell biology and regenerative medicine.” The Heilmeier Award honors a Penn Engineering faculty member whose work is scientifically meritorious a...