Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung. ...
From Penn Today: June 6, 2019: To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]
As stem cells differentiate into functional specialized cells, the process is controlled through signals from their surroundings. In a recent paper published in Nature Materials, this CEMB study suggests that cells may have more control over their fate than previously thought. The study found that cells secrete proteins within hours of being encapsulated in specialized […]
The Lush Prize is a major initiative aiming to bring forward the day when safety testing takes place without the use of animals. It focuses pressure on toxicity testing for consumer products and ingredients, in a way which complements the many projects already addressing the use of animals in medical testing. The Lush Prize rewards […]
(News item prepared by Patience Graybill, Wash U) Researchers have thought that cancer begins when a single cell goes rogue in the body then begins to grow and multiply. Now, they are investigating evidence of more damage when a group of cells breaks off from a colony and more follow, leading to large-scale metastasis. Amit […]
A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and the space between muscles, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, Mount Sinai Beth Israel Medical Center, and the New York University School of […]
Congrats to CEMB PIs Vivek Shenoy, Jason Burdick, Paul Janmey, and Robert Mauck and their new publication on how matching material and cellular timescales effects cell spreading in viscoelastic substrates. Read more in the Proceedings of the National Academy of Sciences.
Two new publications from the lab of Ram Dixit at Washington University in St. Louis indicate how kinesin motor proteins and the microtubule tracks on which they move are regulated in plant cells. Kinesins are proteins that work as “engines” that carry material from one part of the cell to the next. As a transporter […]
Mechanics of Muscle Cells Revealed: Ostap and Sindelar Use Advanced Microscopy to Show Myosin’s Role in Contraction
The Winter Olympics are dominating news headlines, but how do speed skaters and downhill skiers summon the speed to go for the gold? Muscles – contracting slow and fast – allow these athletes to power through the race and sprint to the finish. The remarkable nanometer-sized cellular machines that drive muscle contraction are called myosins. […]
Jason Burdick, Professor in Bioengineering, has been named the recipient of the 2017-18 George H. Heilmeier Faculty Award for Excellence in Research for “pioneering contributions to designing and developing polymers for applications in stem cell biology and regenerative medicine.” The Heilmeier Award honors a Penn Engineering faculty member whose work is scientifically meritorious a...