Healing interventions for spinal disc injuries

By James McGonigle on November 18, 2019 in 2019, Home Page, News, Research

Researchers in the Mauck group have discovered that using a biological inhibitor to prevent cells in the spinal cord from becoming stressed and starting a subpar healing process gives doctors more time to treat injuries before they worsen. “These data show us that treating disc injuries very soon after injury is essential before this transition in […]

Congratulations: Guy M. Genin awarded the Distinguished Faculty Award at Founders Day

By James McGonigle on November 14, 2019 in 2019, Awards/Recognition, Home Page, People

Founders Day commemorates the university’s founding in 1853. It was the action of state senator Wayman Crow, who secured the charter establishing the university, and the educational vision of William Greenleaf Eliot that brought the new school into being. Its purpose: to educate the youth of St. Louis. On February 22, 1853—George Washington’s birthday—Missouri Governor […]

What I Did for My Summer Vacation!

By James McGonigle on November 7, 2019 in 2019, Education, Home Page, RET, Summer Programs

by Amanda Cottone and Jim McGonigle.   Our 2019 Summer Research Experience for Teachers program supported its 3rd cohort consisting of four high school STEM teachers from the Philadelphia area. Over the seven-week program, teachers immersed themselves in mechanobiology research at the University of Pennsylvania to engage in a real-world inquiry that marries science and engineering. […]

[img] Rebecca Wells

Organ-Level Function on a Chip: Bile Duct-on-a-Chip

By James McGonigle on October 8, 2019 in 2019, Home Page, News, People, Primary Investigators, Publications, ... 2 more

In a recent paper published in Hepatology, CEMB’s Rebecca G. Wells, reports on creating the first bile duct-on-a-chip, making it possible for more-complete research to be conducted without the need for human or animal participants. “Bile ducts pose great challenges to researchers because of their location and their complex function and cellular structure, which has […]

[img] Lucia Strader

Plant Cell Mechanobiology Blossoming at WashU

By James McGonigle on August 14, 2019 in 2019, Home Page, News, People, Primary Investigators, Publications, ... 1 more

Plant biologist Lucia Strader in the School of Arts & Sciences at Washington University in St. Louis discovered a cellular transporter that regulates root initiation and progression.  Roots anchor plants in place and allow them to absorb nutrient from soil.  But the process of growing new roots is costly to a plant, and there can […]

Trainee Pilot Awards: Proposal Deadline Nears!

By James McGonigle on August 13, 2019 in 2019, Home Page, Trainee Groups

$10K TRAINEE PILOT AWARDS DOWNLOAD GUIDELINES CEMB encourages applications for up to 3 pilot awards of up to $10,000 each to pairs or groups of CEMB-affiliated trainees to carry out innovative and integrative pilot studies in mechanobiology. Open to any CEMB trainee affiliate (postdocs or graduate students) Each proposal must be submitted by a pair […]

Organs-on-Chips and Organoids: Best of Both Worlds

By James McGonigle on June 11, 2019 in 2019, Home Page, Research

Dan Huh, the Wilf Family Term Assistant Professor in the Department of Bioengineering, focuses his research on creating organs-on-chips: specially manufactured micro-devices with human cells that mimic the natural cellular processes of organs. Recently, the  lab has engineered chips that approximate the functioning of the eye, a placenta and a diseased lung.  This month, Huh published a review of organ-on-a-chip technology in […]

Replicating fetal bone growth process could help heal large bone defects

By James McGonigle on June 10, 2019 in 2019, Home Page, News, Primary Investigators, Research

From Penn Today:  June 6, 2019:  To treat large gaps in long bones, like the femur, which result from bone tumor removal or a shattering trauma, researchers Joel Boerckel’s group and the University of Illinois at Chicago developed a process that partially recreates the bone growth process that occurs before birth. A bone defect of more […]

Cells Control Their Own Fate by Manipulating their Environment

By James McGonigle on April 11, 2019 in 2019, Home Page, News, Research

As stem cells differentiate into functional specialized cells, the process is controlled through signals from their surroundings.  In a recent paper published in Nature Materials, this CEMB study suggests that cells may have more control over their fate than previously thought. The study found that cells secrete proteins within hours of being encapsulated in specialized […]