Principal Investigators

The CEMB Principal Investigators represent a diverse array of institutions and scientific backgrounds, all contributing to research that aims to answer pressing questions in the field of mechanobiology.

Principal Investigators

Working Group 4 co-Leader | Principal Investigator

Keywords: tissue engineering; cell-biomaterial interaction; biomaterials processing; surface characterization and modification of biomaterials; materials testing; stem cell therapy; tissue-engineering scaffolds and biomaterials for the repair of bone and other related musculoskeletal tissue; nerve tissue regeneration utilizing stem cells and other cell types; mechanobiology

Co-Director | Principal Investigator

Keywords: extracellular matrix; microenvironment; adhesion receptor signaling; mechanotransduction; integrins; cadherins; actin; cytoskeleton; focal adhesions; matrix remodeling; deformable substrata; micropatterning; cell cycle; proliferation; cyclin-dependent kinases; mouse modeling; tissue mechanics; cardiovascular biology; progeria; mechanobiology
Jason Burdick

Principal Investigator

Keywords: polymeric biomaterials; cell-matrix interactions; biomaterials; cell mechanosensing; tissue engineering; bioengineered therapeutics; devices and drug delivery; mechanobiology

2018 SEED Grant Recipient

keywords: mechanotransductive feedback, cytoskeletal dynamics, vasculogenesis, bone development, tissue engineering, endochondral bone regeneration, mechanobiology

Working Group 1 Co-Leader | Principal Investigator

Keywords: membrane bending; actin; Brownian-dynamics; stochastic-growth simulation; analytic theory; mechanobiology

Executive Committee Member | Working Group 4 co-Leader | Principal Investigator

Keywords: cell interaction with environment and subsequent effect on cell function; cell signalling; angiogenesis; stem cell biology; cell adhesion; cell mechanics; micro- and nanofabrication tools; molecular tools; mechanobiology

Principal Investigator

Keywords: nanostructured materials; spintronics; fabrication and modeling of nanostructured materials; time-resolved imaging of spin dynamics; electrochemical deposition; x-ray magnetic circular dichroism studies; nanoscience; mechanobiology
Derrick Dean

Director of Diversity | Principal Investigator

Keywords: micro- and nanostructured polymer composites; scaffolding; tissue engineering; drug delivery; mechanobiology

Principal Investigator

Keywords: stem cell differentiation; matrix stiffness and elasticity; nuclear plasticity; polymer synthesis and assembly; bioengineered therapeutics; cell engineering; mechanobiology
[img] Dixit

Working Group 2 Co-Leader | Principal Investigator

Keywords: plant cell morphogenesis; cortical microtubule cytoskeleton; plant cell wall; mechanobiology; microtubule plus-end and minus-end targeting proteins; microtubule severing; microtubule bundling; microtubule self-organization; kinesins

Principal Investigator

Keywords: conversion of biomass into chemicals; interfacing the catalytic depolymerization of biomass with microbial utilization; cell stimulus response; liquid-phase; heterogeneous catalysis; mechanobiology

Co-Director | Principal Investigator

Keywords: biophysical methods; biophysics; cell biology; extracellular matrix; substrates; periplasm configuration; cell adhesion and spreading; auxin; arabinogalactins; electrical signalling; mechanobiology

Principal Investigator

Keywords: mapping domain motions of motor proteins and ribosomal elongation factors; mechanics of the energy transduction mechanism; enzymatic reactions; myosin; dynein; kinesin; nanometer tracking of single fluorescent molecules and fluorescent probes; optical traps; mechanobiology

2018 SEED GRANT RECIPIENT

Keywords: Stem cell, curvature, matrix stiffness, hydrogel, devices, polymeric biomaterials, 3D bioprinting, biofabrication
[img] Haswell

Director of Research | Principal Investigator

Keywords: mechanosensitive ion channels, mechanosensitivity, cell signaling, programmed cell death, biochemical and molecular genetic approaches, live-imaging, electrophysiology; mechanobiology
[img] Dan Huh

Principal Investigator

Keywords: bioengineered therapeutics; devices and drug delivery; cellular engineering; tissue engineering; organs-on-chips; mechanobiology

Principal Investigator

Keywords: cardiac function; bioengineering; device development; mechanobiology
[img} Rajan Jain

Principal Investigator

Keywords: nuclear architecture; gene regulation; chromatin; epigenetics; 3D genome organization; heart development; stem cell biology; mechanobiology
[img] Janmey

Working Group 2 Co-Leader | Principal Investigator

Keywords: cytoskeleton; phosphoinositide signaling; cell mechanics; actin; PIP2; gel; astrocyte; fibrin; gelsolin; cellular engineering; bioengineered therapeutics; devices and drug delivery; cardiovascular and pulmonary cell and tissue mechanics; mechanobiology

2018 SEED Grant Recipient

Keywords: graphene, adhesion molecules, integrin, mechanobiology

2018 SEED GRANT RECIPIENT

KEYWORDS: epigenetics, chromosomes, gene regulation, genome structure, cell fate determination, macromolecular machines, intracellular trafficking, vesicles, super-resolution microscopy, nucleosomes, mechanobiology

Director of Knowledge Transfer | Working Group 3 Co-Leader | Principal Investigator

Keywords: soft tissue mechanobiology; physiologic processes; patho-physiologic processes; tissue engineering; technological development; mesenchymal stem cells; mechanobiologic cultures; cell scaffolding; mechanobiology

2018 SEED Grant Recipient

Keyword: alveolar macrophage, lung stiffness, inflammation, adaptive immunity,
[img] Elijah Nyairo

Principal Investigator

Keywords: polymeric scaffolds; nanobiomaterials; nanofibers; electrospinning; bone and tissue repair; biodegradable polymers; drug delivery; mechanobiology

Working Group 1 Co-Leader | Principal Investigator

Keywords: cytoskeleton; molecular motors; cell signalling; muscle contraction; cell structure; intracellular transport; myosin; dynein; kinesin; mechanobiology

2018 SEED Grant Recipient

Keywords: matrix stiffness, epithelial cells, ECM, mechanobiology, YAP, cell migration, micro-fabrication, hydrogel synthesis, tumor microenvironment, cancer mechanobiology, computational modeling, cell-matrix interactions
[img] Barbara Pickard

Principal Investigator

Keywords: electromechanical signalling in plants; mechanosensing and responses; arabinoglactan protein; cell wall; mechanobiology
[img] Benjamin Prosser

Principal Investigator

Keywords: mechanotransduction; mechanical signalling; mechanical stress; cytoskeleton; cardiac physiology and pathology; mechanobiology
[img] Shenoy

Director | Principal Investigator

Keywords: physical properties and growth mechanisms of 2D materials; nanocrystals and nanowires; mechanics of biological systems and materials; materials for energy; mechanobiology
[img] Lucia Strader

Principal Investigator

Keywords: auxin, plant morphogenesis, cell division and expansion, environmental response, biosynthesis, cell transport, storage forms, indole-3-butyric acid (IBA), mechanobiology
[img] Dave Thirumalai

Principal Investigator

Keywords: equilibrium and non equalibrium statistical mechanics; polymer-colloid interaction; dynamics of protein folding; biochemistry; RNA molecules; conformations in proteins; environmental response; role of chaperone in protein folding; molecular machines; DNA shapes due to stretching and condensation; mechanobiology
[img] Rebecca Wells

Director of Education | CEMB Executive Committee Member | Principal Investigator

Keywords: Hepatic stellate cells, liver fibrosis, TGF-ß, portal fibroblasts, biliary atresia, liver mechanics, fibronectin; mechanobiology