Principal Investigators

The CEMB Principal Investigators represent a diverse array of institutions and scientific backgrounds, all contributing to research that aims to answer pressing questions in the field of mechanobiology.

Principal Investigators

CEMB Working Group 4 Leader

Keywords: tissue engineering; cell-biomaterial interaction; biomaterials processing; surface characterization and modification of biomaterials; materials testing; stem cell therapy; tissue-engineering scaffolds and biomaterials for the repair of bone and other related musculoskeletal tissue; nerve tissue regeneration utilizing stem cells and other cell types; mechanobiology

CEMB Co-Director

Keywords: extracellular matrix; microenvironment; adhesion receptor signaling; mechanotransduction; integrins; cadherins; actin; cytoskeleton; focal adhesions; matrix remodeling; deformable substrata; micropatterning; cell cycle; proliferation; cyclin-dependent kinases; mouse modeling; tissue mechanics; cardiovascular biology; progeria; mechanobiology
Jason Burdick

CEMB Director of Knowledge Transfer

Keywords: polymeric biomaterials; cell-matrix interactions; biomaterials; cell mechanosensing; tissue engineering; bioengineered therapeutics; devices and drug delivery; mechanobiology

2018 SEED Grant Recipient

Cells are able to respond to a variety of mechanical stimuli, from fluid shear blood vessel cells, to the changing mechanical properties of the environment in which a cancer cell resides. Cells interpret these mechanical stimuli through a process called “mechanosensation” and translate them …

CEMB Working Group 1 Co-Leader

Keywords: membrane bending; actin; Brownian-dynamics; stochastic-growth simulation; analytic theory; mechanobiology

CEMB Executive Committee Member

Keywords: cell interaction with environment and subsequent effect on cell function; cell signalling; angiogenesis; stem cell biology; cell adhesion; cell mechanics; micro- and nanofabrication tools; molecular tools; mechanobiology

CEMB Principal Investigator

Keywords: nanostructured materials; spintronics; fabrication and modeling of nanostructured materials; time-resolved imaging of spin dynamics; electrochemical deposition; x-ray magnetic circular dichroism studies; nanoscience; mechanobiology
Derrick Dean

CEMB Director of Diversity

Keywords: micro- and nanostructured polymer composites; scaffolding; tissue engineering; drug delivery; mechanobiology

CEMB Principal Investigator

Keywords: stem cell differentiation; matrix stiffness and elasticity; nuclear plasticity; polymer synthesis and assembly; bioengineered therapeutics; cell engineering; mechanobiology
[img] Dixit

CEMB Working Group 2 Co-Leader

Keywords: plant cell morphogenesis; cortical microtubule cytoskeleton; plant cell wall; mechanobiology; microtubule plus-end and minus-end targeting proteins; microtubule severing; microtubule bundling; microtubule self-organization; kinesins

CEMB Principal Investigator

Keywords: conversion of biomass into chemicals; interfacing the catalytic depolymerization of biomass with microbial utilization; cell stimulus response; liquid-phase; heterogeneous catalysis; mechanobiology

CEMB Co-Director

Keywords: biophysical methods; biophysics; cell biology; extracellular matrix; substrates; periplasm configuration; cell adhesion and spreading; auxin; arabinogalactins; electrical signalling; mechanobiology

CEMB Principal Investigator

Keywords: mapping domain motions of motor proteins and ribosomal elongation factors; mechanics of the energy transduction mechanism; enzymatic reactions; myosin; dynein; kinesin; nanometer tracking of single fluorescent molecules and fluorescent probes; optical traps; mechanobiology
[img] Haswell

CEMB Director of Research

Keywords: mechanosensitive ion channels, mechanosensitivity, cell signaling, programmed cell death, biochemical and molecular genetic approaches, live-imaging, electrophysiology; mechanobiology
[img] Holzbaur

CEMB Principal Investigator

Key words: microtubule-based motility; dynein; cytoplasmic dynein; dynactin; microtubule motors; microtubules; microtubule dynamics; EB1; mechanobiology
[img] Dan Huh

CEMB Principal Investigator

Keywords: bioengineered therapeutics; devices and drug delivery; cellular engineering; tissue engineering; organs-on-chips; mechanobiology

CEMB Principal Investigator

Keywords: cardiac function; bioengineering; device development; mechanobiology
[img} Rajan Jain

CEMB Principal Investigator

Keywords: nuclear architecture; gene regulation; chromatin; epigenetics; 3D genome organization; heart development; stem cell biology; mechanobiology
[img] Janmey

CEMB Working Group 2 Co-Leader

Keywords: cytoskeleton; phosphoinositide signaling; cell mechanics; actin; PIP2; gel; astrocyte; fibrin; gelsolin; cellular engineering; bioengineered therapeutics; devices and drug delivery; cardiovascular and pulmonary cell and tissue mechanics; mechanobiology

2018 SEED Grant Recipient

This SEED aims to probe cell-matrix adhesion by use of atomically thin conducting materials such as graphene sheets as interfacial layers. By spatially patterning and varying the conductivity of graphene sheets, the interactions of adhesion molecules such as integrin. More specifically the …

CEMB Working Group 3 Co-Leader

Keywords: soft tissue mechanobiology; physiologic processes; patho-physiologic processes; tissue engineering; technological development; mesenchymal stem cells; mechanobiologic cultures; cell scaffolding; mechanobiology

2018 SEED Grant Recipient

Specialized immune cells in the lung, called alveolar macrophages, control how much inflammation the lungs generate after inhalation of an irritant (like smoke) or a germ. Deciding how much inflammation to cause is important. If the lungs don’t generate enough inflammation, the body won’t be …
[img] Elijah Nyairo

CEMB Principal Investigator

Keywords: polymeric scaffolds; nanobiomaterials; nanofibers; electrospinning; bone and tissue repair; biodegradable polymers; drug delivery; mechanobiology

CEMB Working Group 1 Co-Leader

Keywords: cytoskeleton; molecular motors; cell signalling; muscle contraction; cell structure; intracellular transport; myosin; dynein; kinesin; mechanobiology

2018 SEED Grant Recipient

Collectively migrating cells sense matrix stiffness through adhesions and cytoskeletal forces. We have recently shown that mechanical priming of epithelial cells on a stiff ECM enhances their future migration, even after they move to a soft ECM. This storage of past mechano-activation in …
[img] Barbara Pickard

CEMB Principal Investigator

Keywords: electromechanical signalling in plants; mechanosensing and responses; arabinoglactan protein; cell wall; mechanobiology
[img] Benjamin Prosser

CEMB Principal Investigator

Keywords: mechanotransduction; mechanical signalling; mechanical stress; cytoskeleton; cardiac physiology and pathology; mechanobiology
[img] Elizabeth Rhoades

CEMB Principal Investigator

Keywords: intrinsically disordered proteins, protein conformation, protein dynamics, protein-protein interactions, protein-membrane interactions, single-molecule optical techniques, tau, α-synuclein, islet amyloid polypeptide, troponin
[img] Shenoy

CEMB Director

Keywords: physical properties and growth mechanisms of 2D materials; nanocrystals and nanowires; mechanics of biological systems and materials; materials for energy; mechanobiology
[img] Lucia Strader

CEMB Working Group 3 Co-Leader

Keywords: auxin, plant morphogenesis, cell division and expansion, environmental response, biosynthesis, cell transport, storage forms, indole-3-butyric acid (IBA), mechanobiology
[img] Dave Thirumalai

CEMB Principal Investigator

Keywords: equilibrium and non equalibrium statistical mechanics; polymer-colloid interaction; dynamics of protein folding; biochemistry; RNA molecules; conformations in proteins; environmental response; role of chaperone in protein folding; molecular machines; DNA shapes due to stretching and condensation; mechanobiology
[img] Rebecca Wells

CEMB Director of Education | CEMB Executive Committee Member

Keywords: Hepatic stellate cells, liver fibrosis, TGF-ß, portal fibroblasts, biliary atresia, liver mechanics, fibronectin; mechanobiology
[img] Beth Winkelstein

CEMB Principal Investigator

Keywords: cellular/molecular factors that lead to chronic pain; mechanical loading; biomechanics; neuroimmunology; neuroengineering; orthopaedic bioengineering; mechanobiology