Meet Our Team

A wide range of biological and physiological processes are modulated by the capability of the cell to respond and sense to mechanical stress/force, yet these mechanical forces are poorly understood at the molecular scale with molecular specificity. For the intricate details and better understanding of these mechanical forces, I am working on Force-FRET (Forster resonance energy transfer) sensors project, which involves designing and characterization of new Force-FRET probes in solution at single molecule level. These Force-FRET probes will be further incorporated into protein of interest (such as Nesprin and Myosin I) and will be calibrated for its mechanical sensitivity by measuring force vs FRET efficiency using combined optical trap/TIRF microscopy and performing fluorescence lifetime imaging