I am interested in how cytoskeletal geometries influence intracellular transport and mechanosignalling. I want to determine how the different cytoskeletal environments found in cells influence the movement of molecular motors and their associated cargoes and filament systems. My research focuses on engineering different cytoskeletal patterns and testing motor movement in a reconstituted in vitro system. With these minimalized environments, we can determine the cytoskeletal factors necessary for directing transport and signaling.
Ms. Masucci is currently working in the lab of Dr. E. Michael Ostap.