NOTE: All Working Group meetings are meant to be all-hands meetings, and are intended for discussion among the entire center, not those already expert in the particular area. Everyone should try to attend all WG meetings.
Working Group 2 Meeting: How cells adapt to and change their mechanical environment
Organizers: Ram Dixit and Paul Janmey
Ryan J. Petrie, PhD., Assistant Professor, Drexel Biology
Title: Intracellular pressure and cell dynamics
Actomyosin contractility is well-known to generate the traction forces cells use to remodel their environment. Our recent work shows that myosin II activity can also increase intracellular hydraulic pressure to govern the motility of both fibroblasts and epithelial cells.
Celeste Morley, M.D., Ph.D., Associate Professor, Pathology & Immunology, Washington University in Saint Louis
Title: Mechanosensing in macrophages
Tissue-resident macrophages delicately balance secretion of pro-inflammatory, anti-pathogen signals with anti-inflammatory, pro-healing functions to maintain homeostasis. We are studying how substrate stiffness serves as one input that macrophages use to determine how to respond to other incoming extracellular signals.
Time: 1:30 – 3:00 p.m. EST
Location: LRSM Building at 3231 Walnut Street, ROOM 112A, CEMB Conference Room, University of Pennsylvania or remotely via GoToMeeting